Biomedical Engineering Department, Florida International University, 10555 W Flagler St., Miami, FL 33174, USA.
Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.
Biosensors (Basel). 2022 Sep 24;12(10):786. doi: 10.3390/bios12100786.
Cervical cancer is one of the most significant global health inequities of our time and is the fourth most common cancer in women worldwide, disproportionally affecting developing countries where the disease burden is 84%. Sometimes referred to as preventable cancer, it progresses slowly, providing a window of time for routine screening in which pre-cancerous lesions can be identified and treated. The high mortality rate can be attributed to many reasons, including the high cost of cytology-based screening, lack of human resources to conduct screening, and inadequate preventive medicine services and systems. Due to its slow progression, early intervention is feasible with appropriate screening. However, the standard screening procedures require access to lab-based tests and physician expertise. Several imaging devices have been introduced in the literature to aid cervical screening in low-resource settings. This review details the instrumentation and clinical testing of devices currently deployed in low-resource locations worldwide. The devices' imaging, portability, illumination, and power requirements (among other metrics) are documented with specifics of human pilot studies conducted with these tools.
宫颈癌是当今全球重大健康不平等问题之一，也是全世界女性中第四常见的癌症，在发展中国家发病率较高，占比达 84%。宫颈癌有时被称为可预防的癌症，其发展缓慢，为常规筛查提供了一个时间窗口，在此期间可以发现癌前病变并进行治疗。高死亡率的原因有很多，包括细胞学筛查成本高、缺乏进行筛查的人力资源以及预防医学服务和系统不足。由于其发展缓慢，早期干预是可行的，只要进行适当的筛查。但是，标准的筛查程序需要实验室检测和医生的专业知识。文献中已经介绍了几种成像设备，以帮助在资源匮乏的环境中进行宫颈筛查。本综述详细介绍了目前在全球资源匮乏地区部署的设备的仪器和临床检测。记录了设备的成像、便携性、照明和电源要求（以及其他指标），并详细介绍了使用这些工具进行的人体初步研究。
