Department of Neurology, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Neurosci Bull. 2010 Feb;26(1):47-54. doi: 10.1007/s12264-010-0816-4.
To assess whether quick cognitive screening test (QCST) could quickly identify mild cognitive impairment (MCI).
QCST and a full set of standardized neuropsychological tests, including mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA) were performed. A total number of 121 cases of MCI [41 cases of amnestic MCI-single domain (aMCI-s); 44 of amnestic MCI-multiple domain (aMCI-m); 36 of nonamnestic MCI (naMCI)], 79 cases of mild Alzheimer's disease (AD) and 186 healthy elderly volunteers were employed in the present study. All the participants (55-85 years old) had an educational level no less than 5 years. QCST subtests included word list recall, naming test, animal fluency test, similarity test, color trail-1min, clock drawing test, finger construction test, and digit span test. The total score of QCST was 90 points, 10 points for each index of subtests.
The total scores of QCST in MCI, AD and the control groups were (58.13+/-8.18), (44.53+/-10.54) and (72.92+/-6.85) points, respectively. According to the educational level, the cut off scores of participants with an educational level of 5-8 years, 9-12 years and more than 13 years were 63, 65 and 68 points, respectively. The sensitivity and specificity of QCST in detection of MCI were 87.6% (85.7% for aMCI-s, 90.1% for aMCI-m and 89.5% for naMCI) and 84.3%, respectively. The area under the curve was 0.923 (95% CI: 0.892-0.953). Delayed memory, color trail-1min and similarity test could help distinguish between aMCI and naMCI.
QCST may have a good sensitivity and specificity for MCI detection, which warrants its further clinical application.
评估快速认知筛查测试（QCST）是否能快速识别轻度认知障碍（MCI）。
进行 QCST 和一套标准化神经心理学测试，包括简易精神状态检查（MMSE）和蒙特利尔认知评估（MoCA）。本研究共纳入 121 例 MCI 患者[41 例单纯性遗忘型 MCI（aMCI-s）；44 例多领域遗忘型 MCI（aMCI-m）；36 例非遗忘型 MCI（naMCI）]、79 例轻度阿尔茨海默病（AD）患者和 186 名健康老年人志愿者。所有参与者（55-85 岁）的教育水平均不少于 5 年。QCST 子测验包括单词回忆、命名测验、动物流畅性测验、相似性测验、1 分钟色连线测验、画钟测验、手指构造测验和数字广度测验。QCST 的总分为 90 分，每个子测验的指标得分为 10 分。
MCI、AD 和对照组的 QCST 总分分别为（58.13+/-8.18）、（44.53+/-10.54）和（72.92+/-6.85）分。根据教育水平，教育年限为 5-8 年、9-12 年和超过 13 年的参与者的截断分数分别为 63、65 和 68 分。QCST 检测 MCI 的敏感性和特异性分别为 87.6%（aMCI-s 为 85.7%，aMCI-m 为 90.1%，naMCI 为 89.5%）和 84.3%。曲线下面积为 0.923（95%CI：0.892-0.953）。延迟记忆、1 分钟色连线测验和相似性测验有助于区分 aMCI 和 naMCI。
QCST 对 MCI 的检测可能具有较好的敏感性和特异性，值得进一步临床应用。
