Singh Harminder, Singh Prabhakar, Tiwari Pavan, Dey Vivek, Dulhani Navin, Singh Amita
Department of Pharmacology, Government Medical College, Jagdalpur (CG), India.
Indian J Dermatol. 2009;54(4):338-41. doi: 10.4103/0019-5154.57609.
Cutaneous disorders during HIV infection are numerous and skin is often the first and only organ affected during most of the course of HIV disease. Some Cutaneous disorders reflect the progression of HIV disease; though the relation is still controversial.
The objective of this study, conducted at a tertiary care centre in Bastar, Jagdalpur, is to estimate the status of cutaneous manifestation in HIV-infected patients and its relationship with CD4 cell counts.
We enrolled 137 HIV positive subjects. Demographic information such as age, gender, weight, height, socioeconomic status, and educational status were recorded. Laboratory parameter (CD4 counts) and treatment regimen were noted. Patients were examined for skin disorders by a dermatologist. Data were analyzed using chi-square test for categorical variables.
Majority of the patients were from rural area (65.69%) and belonged to a low socioeconomic and educational status. 30.65% of the patients were housewives, 23.35% drivers, and 16.78% labourers. Predominant mode of transmission was heterosexual contact (94.16%). Most common HIV-related dermatological manifestations were seborrheic dermatitis (74.16%), xerosis (52.5%), generalized skin hyperpigmentation 56 (46.67%), onychomycosis 53 (44.16%), pruritic papular eruption 27 (22.5%), oral candidiasis 21 (17.5%), photo dermatitis 21 (17.5%), and scabies 4 (3.33%). Significant correlation with low CD4+ cell counts was found for oral candidiasis (P < 0.0001) and Kaposi's sarcoma (P = 0.03), while other disorders such as seborrheic dermatitis (P = 0.22), xerosis (P = 0.25), and onychomycosis (P = 0.08) were not statistically significant.
This study showed high prevalence of dermatological manifestations in HIV-infected subjects, and they occur more frequently with progression of HIV and decline in immune functions. Therefore, early diagnosis and management of skin disorders can improve the quality of life of HIV-infected subjects.
HIV感染期间的皮肤疾病众多，在HIV疾病的大部分病程中，皮肤往往是首个且唯一受影响的器官。一些皮肤疾病反映了HIV疾病的进展，尽管这种关系仍存在争议。
本研究在贾格达布尔巴斯塔尔的一家三级护理中心进行，旨在评估HIV感染患者的皮肤表现状况及其与CD4细胞计数的关系。
我们招募了137名HIV阳性受试者。记录了年龄、性别、体重、身高、社会经济地位和教育程度等人口统计学信息。记录了实验室参数（CD4计数）和治疗方案。由皮肤科医生对患者进行皮肤疾病检查。使用卡方检验对分类变量进行数据分析。
大多数患者来自农村地区（65.69%），社会经济和教育地位较低。30.65%的患者是家庭主妇，23.35%是司机，16.78%是劳动者。主要传播方式是异性接触（94.16%）。最常见的HIV相关皮肤表现为脂溢性皮炎（74.16%）、皮肤干燥（52.5%）、全身性皮肤色素沉着（46.67%）、甲癣（44.16%）、瘙痒性丘疹疹（22.5%）、口腔念珠菌病（17.5%）、光性皮炎（17.5%）和疥疮（3.33%）。发现口腔念珠菌病（P < 0.0001）和卡波西肉瘤（P = 0.03）与低CD4 + 细胞计数有显著相关性，而脂溢性皮炎（P = 0.22）、皮肤干燥（P = 0.25）和甲癣（P = 0.08）等其他疾病无统计学意义。
本研究表明HIV感染受试者中皮肤表现的患病率较高，且随着HIV进展和免疫功能下降而更频繁发生。因此，皮肤疾病的早期诊断和管理可改善HIV感染受试者的生活质量。
