Spira R, Mignard M, Doutre M S, Morlat P, Dabis F
INSERM Unit 330, Université Victor Segalen Bordeaux 2, France.
Arch Dermatol. 1998 Oct;134(10):1208-12. doi: 10.1001/archderm.134.10.1208.
To estimate the current extent of cutaneous disorders in a large population of ambulatory and hospitalized human immunodeficiency virus (HIV)-infected patients and to describe characteristics associated with the presence of current skin manifestations.
Cross-sectional survey.
Hospital units participating in the hospital-based information system of the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine, southwestern France.
All the patients seen by physicians between November 18 and December 20, 1996, in the participating units (hospital ward, outpatient clinic, or day hospital).
Prevalence and cumulative incidence of cutaneous disorders.
Four hundred fifty patients at all stages of HIV disease were enrolled; 65.3% had at least 1 skin manifestation during the course of HIV infection. A history of skin disorder was reported for 269 patients (59.8%), and 199 patients (44.2%) had clinical dermatologic manifestations at the time of the study. The most frequent causes of cutaneous disorders were infections (fungal, viral, and bacterial), neoplasia, and miscellaneous disorders. Skin diseases were more likely to be reported in homosexual and bisexual men and in patients with clinically and biologically advanced HIV infection.
Cutaneous disorders occur more frequently as HIV infection advances and immune function deteriorates; however, they are common and of various types throughout the course of HIV disease. Taking cutaneous disorders into consideration for case management is essential to improve quality of life for HIV-infected patients.
评估大量门诊及住院的人类免疫缺陷病毒（HIV）感染患者中皮肤疾病的当前流行程度，并描述与当前皮肤表现存在相关的特征。
横断面调查。
参与法国西南部阿基坦地区艾滋病临床流行病学研究组医院信息系统的医院科室。
1996年11月18日至12月20日期间在参与科室（医院病房、门诊诊所或日间医院）就诊的所有患者。
皮肤疾病的患病率和累积发病率。
纳入了450例处于HIV疾病各阶段的患者；65.3%的患者在HIV感染过程中至少有1种皮肤表现。269例患者（59.8%）报告有皮肤疾病史，199例患者（44.2%）在研究时存在临床皮肤病表现。皮肤疾病最常见的病因是感染（真菌、病毒和细菌）、肿瘤和其他杂症。同性恋和双性恋男性以及临床和生物学上HIV感染进展的患者更有可能报告患有皮肤病。
随着HIV感染进展和免疫功能恶化，皮肤疾病更频繁发生；然而，在HIV疾病的整个过程中，它们很常见且类型多样。在病例管理中考虑皮肤疾病对于提高HIV感染患者的生活质量至关重要。
