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HIV感染患者的皮肤黏膜表现及其与CD4淋巴细胞计数的关系。

Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts.

作者信息

Mirnezami Mina, Zarinfar Nader, Sofian Masoomeh, Botlani Yadegar Bahareh, Rahimi Hoda

机构信息

Department of Dermatology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Department of Infectious Diseases, Arak University of Medical Sciences, Arak, Iran.

出版信息

Scientifica (Cairo). 2020 Aug 11;2020:7503756. doi: 10.1155/2020/7503756. eCollection 2020.

DOI:10.1155/2020/7503756
PMID:32850174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7439183/
Abstract

BACKGROUND

More than 90% of human immunodeficiency virus- (HIV-) infected patients show at least one mucocutaneous manifestation during the course of their disease. The frequency, pattern, and associated factors of these complications vary among different populations.

OBJECTIVE

This study was planned to evaluate the frequency of cutaneous presentations in HIV-infected patients and their association with the count of CD4 cells.

METHODS

A cross-sectional study was conducted on eighty-four HIV-positive patients, who attended the Behavior Consultation Center of Arak University of Medical Sciences. All subjects had a complete physical examination by an expert dermatologist. Further diagnostic procedures were performed, if necessary. Counts of CD4 were determined using flow cytometry.

RESULTS

From 84 patients who enrolled in this study, 95.2% manifested at least one type of mucocutaneous lesions. The most common presentation was xerosis, followed by seborrheic dermatitis, herpes simplex, and oral candidiasis. Oral candidiasis and furuncle were significantly associated with decrease in CD4 cell counts.

CONCLUSIONS

Cutaneous manifestations are common in HIV-positive patients, some of which (oral candidiasis and furuncle) could be applicable as useful clinical indicators to predict the immune status of the patients. Therefore, regular skin examinations are recommended as routine HIV-infected patients' healthcare programs.

摘要

背景

超过90%的人类免疫缺陷病毒（HIV）感染患者在病程中会出现至少一种皮肤黏膜表现。这些并发症的发生率、表现形式及相关因素在不同人群中有所不同。

目的

本研究旨在评估HIV感染患者皮肤表现的发生率及其与CD4细胞计数的相关性。

方法

对84名前往阿拉克医科大学行为咨询中心就诊的HIV阳性患者进行了一项横断面研究。所有受试者均由专业皮肤科医生进行全面的体格检查。如有必要，进行进一步的诊断程序。使用流式细胞术测定CD4计数。

结果

在参与本研究的84名患者中，95.2%表现出至少一种皮肤黏膜病变。最常见的表现是皮肤干燥，其次是脂溢性皮炎、单纯疱疹和口腔念珠菌病。口腔念珠菌病和疖肿与CD4细胞计数减少显著相关。

结论

皮肤表现在HIV阳性患者中很常见，其中一些表现（口腔念珠菌病和疖肿）可作为预测患者免疫状态的有用临床指标。因此，建议将定期皮肤检查作为常规HIV感染患者医疗保健计划的一部分。