UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Eur J Appl Physiol. 2010 May;109(2):323-30. doi: 10.1007/s00421-010-1353-6. Epub 2010 Jan 26.
Measuring the DNA telomere length of skeletal muscle in experienced endurance runners may contribute to our understanding of the effects of chronic exposure to endurance exercise on skeletal muscle. This study compared the minimum terminal restriction fragment (TRF) length in the vastus lateralis muscle of 18 experienced endurance runners (mean age: 42 +/- 7 years) to those of 19 sedentary individuals (mean age: 39 +/- 10 years). The runners had covered almost 50,000 km in training and racing over 15 years. Minimum TRF lengths measured in the muscle of both groups were similar (P = 0.805) and within the normal range. Minimum TRF length in the runners, however, was inversely related to their years spent running (r = -0.63, P = 0.007) and hours spent training (r = -0.52, P = 0.035). Therefore, since exposure to endurance running may influence minimum TRF length, and by implication, the proliferative potential of the satellite cells, chronic endurance running may be seen as a stressor to skeletal muscle.
测量经验丰富的耐力跑运动员骨骼肌中的端粒 DNA 长度，可能有助于我们了解慢性耐力运动对骨骼肌的影响。本研究比较了 18 名经验丰富的耐力跑运动员（平均年龄：42 +/- 7 岁）和 19 名久坐不动的个体（平均年龄：39 +/- 10 岁）的股外侧肌最小末端限制片段（TRF）长度。这些运动员在 15 年的训练和比赛中，总共跑了近 5 万公里。两组肌肉的最小 TRF 长度相似（P = 0.805），且均处于正常范围内。然而，运动员的最小 TRF 长度与他们的跑步年限（r = -0.63，P = 0.007）和训练时间（r = -0.52，P = 0.035）呈负相关。因此，由于耐力跑的暴露可能会影响最小 TRF 长度，进而影响卫星细胞的增殖潜力，因此慢性耐力跑可能被视为骨骼肌的一种应激源。
