Institute of Molecular Biology NAS RA, 7 Hasratyan St., 0014, Yerevan, Armenia.
Neurochem Res. 2010 Jun;35(6):894-8. doi: 10.1007/s11064-010-0126-2. Epub 2010 Jan 26.
In the present study, we evaluated functional activity of the alternative pathway of complement in schizophrenia by measuring the alternative pathway hemolytic activity (AH50) of complement as well as hemolytic activity of the complement C3 component (C3H50) in the blood of patients with schizophrenia and healthy subjects. To assess the influence of neuroleptic treatment on measured parameters, both drug-free and medicated patients were examined. In addition, correlation analysis between AH50 and C3H50 has been performed. The results of the present study clearly demonstrate upregulation of the alternative complement cascade in schizophrenia and activator effect of neuroleptics on complement alternative pathway. Based upon the results obtained we hypothesize that hyperactivation of the alternative complement pathway in schizophrenia is stimulated by apoptotic cells.
在本研究中，我们通过测量补体替代途径溶血活性（AH50）以及精神分裂症患者和健康受试者血液中补体 C3 成分（C3H50）的溶血活性，评估了补体替代途径的功能活性。为了评估神经阻滞剂治疗对测量参数的影响，我们检查了未用药和用药的患者。此外，还进行了 AH50 和 C3H50 之间的相关性分析。本研究的结果清楚地表明，精神分裂症中替代补体级联的上调和神经阻滞剂对补体替代途径的激活作用。根据获得的结果，我们假设精神分裂症中替代补体途径的过度激活是由凋亡细胞刺激的。
