突触重塑，补体系统之功。

Synapse remodeling, compliments of the complement system.

作者信息

Fourgeaud Lawrence, Boulanger Lisa M

机构信息

Division of Biological Sciences, Section of Neurobiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

出版信息

Cell. 2007 Dec 14;131(6):1034-6. doi: 10.1016/j.cell.2007.11.031.

DOI:10.1016/j.cell.2007.11.031

PMID:18083091

Abstract

A growing body of evidence indicates that some proteins known for their immune functions also have distinct nonimmune functions in the normal uninjured central nervous system. In this issue, Stevens et al. (2007) demonstrate an unexpected requirement for molecules of the complement cascade in the remodeling of synaptic connections in the developing visual system.

摘要

越来越多的证据表明，一些以免疫功能著称的蛋白质在正常未受损的中枢神经系统中也具有独特的非免疫功能。在本期杂志中，史蒂文斯等人（2007年）证明，在发育中的视觉系统突触连接重塑过程中，补体级联分子出人意料地发挥了作用。