异常的线粒体动力学——阿尔茨海默病的新治疗靶点？
Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?
机构信息
Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA.
出版信息
Mol Neurobiol. 2010 Jun;41(2-3):87-96. doi: 10.1007/s12035-009-8095-7. Epub 2010 Jan 27.
Abstract
Mitochondria are dynamic organelles that undergo continuous fission and fusion, which could affect all aspects of mitochondrial function. Mitochondrial dysfunction has been well documented in Alzheimer's disease (AD). In the past few years, emerging evidence indicates that an imbalance of mitochondrial dynamics is involved in the pathogenesis of AD. In this review, we discuss in detail the abnormal mitochondrial dynamics in AD and how such abnormal dynamics may impact mitochondrial and neuronal function and contribute to the course of disease. Based on this discussion, we propose that mitochondrial dynamics could be a potential therapeutic target for AD.
摘要
线粒体是具有动态特征的细胞器，不断经历分裂和融合，这可能会影响到线粒体功能的各个方面。线粒体功能障碍在阿尔茨海默病（AD）中已有充分的记载。在过去的几年中，新出现的证据表明，线粒体动力学的失衡与 AD 的发病机制有关。在这篇综述中，我们详细讨论了 AD 中线粒体动力学的异常，以及这种异常动力学如何影响线粒体和神经元功能，并导致疾病的发展。基于这一讨论，我们提出线粒体动力学可能是 AD 的一个潜在治疗靶点。
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