Nemet Dan, Eliakim Alon, Mills Paul J, Meckal Yoav, Cooper Dan M
Child Health and Sports Center, Department of Pediatrics, Meir Medical Center and Sackler School of Medicine, Tel Aviv University, Kfar Saba, Israel.
J Pediatr Endocrinol Metab. 2009 Nov;22(11):995-1007. doi: 10.1515/jpem.2009.22.11.995.
Exercise affects growth and development through a complex interaction between the endocrine, immune, and nervous systems. To date very little is known about how these systems respond to exercise in children or adolescents. Moreover, there are few studies that have examined growth factors, pro-inflammatory cytokines, and peripheral blood mononuclear cell responses to 'real-life' or field exercise solely in girls.
To determine the acute exercise-induced alterations in the growth hormone (GH)-insulinlike growth factor-I (IGF-I) axis, inflammatory cytokines, and certain aspects of immune function (white blood cell [WBC] subpopulations and their associated adhesion molecules) in a group of adolescent girls following a typical cross country practice.
Eight, healthy, postpubertal, high school females, 15-18 years old, performed a single, typical, one hour cross-country practice session. Blood was sampled before and after the session.
Following exercise, lactate increased by 364 +/- 67% (p < 0.001). Significant increases were noted in circulating IL-6 (p < 0.023), TNF-alpha (p < 0.027), IL-1beta (p < 0.047) and IL-1ra (p < 0.002), as well as a substantial increase in GH (p < 0.007). The exercise led to significant increases in all WBC subpopulations and platelets. The most significant changes were observed for natural killer cells (p < 0.0005). The exercise significantly influenced adhesion molecules (such as CD62L, CD54).
These data demonstrate that an intense exercise bout in adolescent females leads to profound increases in inflammatory cytokines, with substantial changes in WBC and adhesion molecules. The role of these frequent, almost-daily perturbations on growth, development and immunity has yet to be determined.
运动通过内分泌、免疫和神经系统之间的复杂相互作用影响生长发育。迄今为止，对于这些系统如何在儿童或青少年中对运动作出反应知之甚少。此外，仅有少数研究仅在女孩中研究了生长因子、促炎细胞因子以及外周血单个核细胞对“实际生活”或野外运动的反应。
确定一组青春期女孩在进行一次典型的越野训练后，运动急性诱导的生长激素（GH）-胰岛素样生长因子-I（IGF-I）轴、炎性细胞因子以及免疫功能某些方面（白细胞[WBC]亚群及其相关黏附分子）的变化。
8名年龄在15 - 18岁、健康的青春期后高中女生进行了一次典型的、时长1小时的越野训练课程。在训练前后采集血样。
运动后，乳酸增加了364±67%（p < 0.001）。循环中的白细胞介素-6（IL-6，p < 0.023）、肿瘤坏死因子-α（TNF-α，p < 0.027）、白细胞介素-1β（IL-1β，p < 0.047）和白细胞介素-1受体拮抗剂（IL-1ra，p < 0.002）显著增加，同时生长激素也大幅增加（p < 0.007）。运动导致所有白细胞亚群和血小板显著增加。自然杀伤细胞的变化最为显著（p < 0.0005）。运动对黏附分子（如CD62L、CD54）有显著影响。
这些数据表明，青春期女性进行一次高强度运动后，炎性细胞因子会大幅增加，白细胞和黏附分子也会发生显著变化。这些频繁的、几乎每日的干扰对生长、发育和免疫的作用尚待确定。
