Department of Sport Science, Sport Health and Performance Enhancement (SHAPE) Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Scand J Med Sci Sports. 2019 Apr;29(4):597-605. doi: 10.1111/sms.13378. Epub 2019 Jan 24.
An acute bout of endurance exercise in adults stimulates a same-day anti-inflammatory response which may affect low-grade chronic inflammation and insulin resistance and benefit cardio-metabolic health. The anti-inflammatory responses to intermittent games-based exercise and to exercise in young people beyond 2 hours post-exercise are unknown. Thus, the purpose of the present study is to examine the anti-inflammatory, glycemic and insulinemic response to games-based activity in adolescents. Following ethical approval and familiarization, 39 adolescents (12.3 ± 0.7 years) completed an exercise (E) and rested (R) trial in a counterbalanced, randomized crossover design. Following a standardized breakfast, participants completed 1-hour games-based activity. Capillary blood samples were taken at baseline, immediately and 1 hour post-exercise, and 30, 60 and 120 minutes following a standardized lunch. A final blood sample was taken the next morning. Data were analyzed using repeated measures ANOVA. IL-6 concentration was higher on day one of the exercise trial (E:3.4 ± 0.4, R:2.7 ± 0.4 pg/mL; P = 0.006), as was the anti-inflammatory IL-6:TNF-α ratio (E:5.53 ± 0.93, R:3.75 ± 0.45; P = 0.027). Levels of the anti-inflammatory cytokine IL-10 increased on day two of the exercise trial (E:2.11 ± 0.23, R:1.66 ± 0.16 pg/mL; P = 0.032). Insulin sensitivity was enhanced on the exercise trial with a reduction in iAUC following the standardized lunch (E:2310 ± 834, R:3122 ± 1443 mU/L × 120 minutes; P < 0.001). Games-based activity stimulated an anti-inflammatory response up to 24 hours post-exercise and improved insulin sensitivity in response to a standardized meal in healthy adolescents. These novel findings suggest that games-based activity is an ecologically valid mode of exercise to elicit beneficial effects on cardio-metabolic risk factors in young people.
成年人进行一次急性耐力运动可刺激当天的抗炎反应，这可能会影响低度慢性炎症和胰岛素抵抗，并有益于心血管代谢健康。目前尚不清楚间歇性基于游戏的运动和年轻人在运动后 2 小时以上的运动的抗炎反应。因此，本研究的目的是研究青少年基于游戏的活动的抗炎、血糖和胰岛素反应。在获得伦理批准和熟悉之后，39 名青少年（12.3±0.7 岁）以平衡、随机交叉设计完成了一项运动（E）和休息（R）试验。在标准早餐后，参与者完成了 1 小时的基于游戏的活动。在基线、运动后即刻和 1 小时以及标准午餐后 30、60 和 120 分钟时采集毛细血管血样。下一个早晨采集最后一个血样。使用重复测量方差分析对数据进行分析。运动试验第一天的白细胞介素-6 浓度更高（E：3.4±0.4，R：2.7±0.4 pg/mL；P=0.006），抗炎白细胞介素-6：肿瘤坏死因子-α 比值也更高（E：5.53±0.93，R：3.75±0.45；P=0.027）。运动试验第二天的抗炎细胞因子白细胞介素-10 水平升高（E：2.11±0.23，R：1.66±0.16 pg/mL；P=0.032）。胰岛素敏感性在运动试验中得到增强，标准化午餐后的 iAUC 降低（E：2310±834，R：3122±1443 mU/L×120 分钟；P<0.001）。基于游戏的活动可刺激运动后 24 小时内的抗炎反应，并改善健康青少年对标准化餐的胰岛素敏感性。这些新发现表明，基于游戏的活动是一种生态有效的运动方式，可以对年轻人的心血管代谢危险因素产生有益影响。
