Paiola G, Tenero L, Piacentini G
Department of Paediatrics, University of Verona, Verona, Italy.
Eur Ann Allergy Clin Immunol. 2009 Oct;41(5):131-5.
Exhaled nitric oxide (NO) is considered the most easily available clinical test to indirectly assess the level of eosinophilic airway inflammation in asthma, and to predict the efficacy of anti-inflammatory treatment with inhaled corticosteroids (ICS). It is possible to measure the level of exhaled NO using online or offline methods. The most widely used online method employs techniques that enable NO in exhaled air to be measured in a single exhalation, calculating the value at the end-expiratory plateau. Because of the correlation between the level of exhaled NO with the level of eosinophilic inflammation in the airway of asthmatic patients, it has been proposed as a clinical marker in the practice of respiratory and allergy physicians with differing targets. In particular it is considered to be highly effective in the diagnosis of allergic asthma, to be capable of identifying those patients with a higher response probability to inhaled corticosteroids, and to a lesser extent, to be of value in contributing to the management of the disease. The possibility of easily taking measurements of FeNO in an office setting even by relatively young children, and the availability of a portable device, opens a significant perspective for the routine use of FeNO evaluation in daily practice.
呼出一氧化氮（NO）被认为是间接评估哮喘中嗜酸性气道炎症水平以及预测吸入性糖皮质激素（ICS）抗炎治疗疗效的最易获得的临床检测方法。可以使用在线或离线方法测量呼出NO的水平。最广泛使用的在线方法采用的技术能够在单次呼气中测量呼出气体中的NO，并在呼气末平台期计算其值。由于哮喘患者气道中呼出NO水平与嗜酸性炎症水平之间存在相关性，因此它已被提议作为呼吸科和过敏科医生在不同目标实践中的临床标志物。特别是，它被认为在过敏性哮喘的诊断中非常有效，能够识别那些对吸入性糖皮质激素反应概率较高的患者，并且在较小程度上，对疾病管理有一定价值。即使是相对年幼的儿童也能在门诊环境中轻松测量呼出一氧化氮（FeNO），并且有便携式设备可用，这为在日常实践中常规使用FeNO评估开辟了重要前景。
