Department of Ophthalmology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, SwedenDepartment of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Acta Paediatr. 2010 May;99(5):658-664. doi: 10.1111/j.1651-2227.2010.01689.x. Epub 2010 Jan 27.
To evaluate the association between gestational age (GA), early and late postnatal growth variables and ophthalmologic outcome in ex-preterm children. methods: Children (GA < 32 weeks, n = 66), previously examined regarding insulin-like growth factor 1 (IGF-1) serum concentrations in relation to ROP, underwent ophthalmologic examination at median 5.6 years. Weight, height, and head circumference (HC) were measured and expressed as SDS. Growth variables were analysed in relation to ophthalmologic outcome.
At follow-up 74% had some ophthalmologic abnormality and 17% had visual impairment. Poor visual acuity was correlated with low GA (r(s) = 0.29, p = 0.019), low weight at 32 weeks (r(s) = 0.30, p = 0.013), and low weight (r(s) = 0.37, p = 0.0025), height (r(s) = 0.41, p = 0.0007) and HC (r(s) = 0.55, p < 0.0001) at follow-up. Hyperopic children (25%) had low neonatal IGF-1 (p = 0.0096) and HC at follow-up (p = 0.022). Poor visual perception was correlated with low early weight (r(s) = 0.38, p = 0.0036) and HC at follow-up (r(s) = 0.39, p = 0.0024). Head circumference at follow-up was correlated with GA (r(s) = 0.40, p = 0.0012), neonatal IGF-1 (r(s) = 0.37, p = 0.0031), and early weight (r(s) = 0.27, p = 0.035).
In very preterm children, early and later postnatal growth is closely related to visual acuity and perception at follow-up. In addition, IGF-1 concentrations and early growth are correlated with head circumference and refraction at follow-up.
评估胎龄（GA）、早后期生长变量与早产儿眼科结局的关系。方法：对 66 例（GA<32 周）胰岛素样生长因子 1（IGF-1）血清浓度与 ROP 相关的患儿进行检查，中位随访时间 5.6 年，行眼科检查。体重、身高和头围（HC）用 SDS 表示。分析生长变量与眼科结局的关系。结果：随访时 74%的患儿存在眼部异常，17%的患儿视力受损。视力差与低 GA（r(s)=0.29，p=0.019）、32 周低体重（r(s)=0.30，p=0.013）、随访时低体重（r(s)=0.37，p=0.0025）、身高（r(s)=0.41，p=0.0007）和 HC（r(s)=0.55，p<0.0001）相关。远视患儿（25%）新生儿 IGF-1 水平较低（p=0.0096），随访时 HC 较低（p=0.022）。视觉感知较差与早期低体重（r(s)=0.38，p=0.0036）和随访时 HC 较低（r(s)=0.39，p=0.0024）相关。随访时 HC 与 GA（r(s)=0.40，p=0.0012）、新生儿 IGF-1（r(s)=0.37，p=0.0031）和早期体重（r(s)=0.27，p=0.035）相关。结论：在极早产儿中，早期和后期的生长与随访时的视力和视力感知密切相关。此外，IGF-1 浓度和早期生长与随访时的头围和屈光度相关。
