Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035-003 Porto Alegre, RS, Brazil.
J Neuroinflammation. 2010 Jan 27;7:6. doi: 10.1186/1742-2094-7-6.
Alzheimer's disease is the most common dementia in the elderly, and the potential of peripheral biochemical markers as complementary tools in the neuropsychiatric evaluation of these patients has claimed further attention.
We evaluated serum levels of S100B and neuron-specific enolase (NSE) in 54 mild, moderate and severe Alzheimer's disease (AD) patients and in 66 community-dwelling elderly. AD patients met the probable NINCDS-ADRDA criteria. Severity of dementia was ascertained by the Clinical Dementia Rating (CDR) scale, cognitive function by the Mini Mental State Examination (MMSE), and neuroimage findings with magnetic resonance imaging. Serum was obtained from all individuals and frozen at -70 degrees C until analysis.
By comparing both groups, serum S100B levels were lower in AD group, while serum NSE levels were the same both groups. In AD patients, S100B levels were positively correlated with CDR scores (rho = 0.269; p = 0.049) and negatively correlated with MMSE scores (rho = -0.33; P = 0.048). NSE levels decreased in AD patients with higher levels of brain atrophy.
The findings suggest that serum levels of S100B may be a marker for brain functional condition and serum NSE levels may be a marker for morphological status in AD.
阿尔茨海默病是老年人中最常见的痴呆症，外周生化标志物作为这些患者神经精神评估的补充工具的潜力引起了更多关注。
我们评估了 54 名轻度、中度和重度阿尔茨海默病（AD）患者和 66 名居住在社区的老年人的血清 S100B 和神经元特异性烯醇化酶（NSE）水平。AD 患者符合可能的 NINCDS-ADRDA 标准。痴呆症的严重程度通过临床痴呆评定量表（CDR）量表确定，认知功能通过简易精神状态检查（MMSE）确定，神经影像学发现通过磁共振成像确定。从所有个体中获得血清并在-70°C 下冷冻直至分析。
通过比较两组，AD 组的血清 S100B 水平较低，而两组的血清 NSE 水平相同。在 AD 患者中，S100B 水平与 CDR 评分呈正相关（rho = 0.269；p = 0.049），与 MMSE 评分呈负相关（rho = -0.33；P = 0.048）。大脑萎缩程度较高的 AD 患者的 NSE 水平下降。
这些发现表明，血清 S100B 水平可能是大脑功能状况的标志物，而血清 NSE 水平可能是 AD 患者形态学状态的标志物。
