Università degli Studi di Milano, Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Via Pascal 36, 20133 Milan, Italy.
Vaccine. 2010 Mar 24;28(15):2700-4. doi: 10.1016/j.vaccine.2010.01.021. Epub 2010 Jan 25.
During the 2006-2007 season, 19 HIV-uninfected and 33 HIV-infected children and adolescents with full immunovirologic response to HAART were immunized against influenza and subsequently followed up. One month post-immunization all subjects had protective antibodies titres which persisted for the whole influenza season. Seven vaccinees (four HIV-infected and three HIV-uninfected) were found to be infected by influenza viruses during the epidemic, but disease was lab-confirmed only in two HIV-infected subjects. Both presented a benign clinical course and were infected by an A/Brisbane/10/07-H3N2-like virus. These data indicate that HIV-infected subjects benefit from routine seasonal influenza vaccination.
在 2006-2007 赛季，19 名未感染 HIV 的儿童和青少年以及 33 名对高效抗逆转录病毒治疗（HAART）有完全免疫病毒学反应的 HIV 感染儿童和青少年接受了流感疫苗接种，并随后进行了随访。免疫接种后 1 个月，所有受试者均产生了保护性抗体滴度，且该滴度在整个流感季节持续存在。在流感流行期间，有 7 名（4 名 HIV 感染者和 3 名 HIV 未感染者）疫苗接种者被发现感染了流感病毒，但仅在 2 名 HIV 感染者中确诊为疾病。这两名患者均表现出良性的临床病程，且感染的是 A/Brisbane/10/07-H3N2 样病毒。这些数据表明，HIV 感染者从常规季节性流感疫苗接种中受益。
