乳源转化生长因子-β与婴儿免疫应答。

Milk-derived transforming growth factor-beta and the infant immune response.

机构信息

Women's and Children's Health Research Institute, Women's and Children's Hospital, North Adelaide, South Australia.

出版信息

J Pediatr. 2010 Feb;156(2 Suppl):S21-5. doi: 10.1016/j.jpeds.2009.11.016.

DOI:10.1016/j.jpeds.2009.11.016

PMID:20105660

Abstract

Breast milk cytokines have the potential to regulate the immune response to food antigens in infants. Cytokines are present in all mammalian milks and are capable of inhibiting excess inflammation and modulating epithelial proliferation. There are a range of candidate cytokines in milk such as transforming growth factor-beta (TGF-beta), the major cytokine present, and interleukin-10, which play a role in immune regulation in the developing infant. This article will be a review of the current literature with regard to TGF-beta in infant immune development. Our data on supplementation of formula with rTGF-beta2 will be discussed in view of the current literature. Oral antigen exposure also plays an important role in priming the developing immune response. The influence of early introduction of oral beta-lactoglobulin in allergy prone rat pups will also be discussed.

摘要

母乳细胞因子有可能调节婴儿对食物抗原的免疫反应。细胞因子存在于所有哺乳动物的乳汁中，能够抑制过度炎症反应，并调节上皮细胞增殖。乳汁中有多种候选细胞因子，如转化生长因子-β（TGF-β），这是主要的细胞因子，以及白细胞介素-10，它们在婴儿发育中的免疫调节中发挥作用。本文将对 TGF-β在婴儿免疫发育中的现有文献进行综述。我们将根据现有文献讨论 rTGF-β2 配方补充的相关数据。口服抗原暴露也在启动发育中的免疫反应中起着重要作用。还将讨论早期引入易过敏大鼠幼仔口腔β-乳球蛋白的影响。