Department of Virology, Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden.
J Gen Virol. 2010 May;91(Pt 5):1262-74. doi: 10.1099/vir.0.016618-0. Epub 2010 Jan 27.
The genus Hantavirus (family Bunyaviridae) includes negative-strand RNA viruses that are carried by persistently infected rodent and insectivore species. Puumala virus (PUUV), carried by bank voles (Myodes glareolus), is a pathogenic hantavirus that causes outbreaks of mild haemorrhagic fever with renal syndrome across Europe. In northern Europe, PUUV is represented by several genetic lineages that are maintained by distinct phylogroups of bank voles. The present study describes sequences of new PUUV strains recovered from northern and southern regions of Scandinavia and compares phylogenetic relationships between north-European PUUV strains and M. glareolus. This analysis revealed contradictions in phylogenetic clustering and remarkable differences in estimated divergence times between the lineages of PUUV and its host, suggesting that the established PUUV lineages did not co-diverge with the distinct phylogroups of M. glareolus that carry them at present.
汉坦病毒属（布尼亚病毒科）包括由持续感染的啮齿动物和食虫动物携带的负链 RNA 病毒。由田鼠（Myodes glareolus）携带的普马拉病毒（PUUV）是一种致病性汉坦病毒，可在欧洲引发轻度出血性发热伴肾综合征疫情。在北欧，PUUV 由几个遗传谱系组成，由不同的田鼠种群维持。本研究描述了从斯堪的纳维亚北部和南部地区回收的新 PUUV 毒株的序列，并比较了北欧 PUUV 株与 M. glareolus 之间的系统发育关系。该分析揭示了系统发育聚类中的矛盾以及 PUUV 与其宿主之间估计的分歧时间之间的显著差异，表明已建立的 PUUV 谱系并未与目前携带它们的 M. glareolus 的不同种群共同进化。
