自闭症的严重程度与有毒金属体内负荷及红细胞谷胱甘肽水平相关。
The severity of autism is associated with toxic metal body burden and red blood cell glutathione levels.
作者信息
Adams J B, Baral M, Geis E, Mitchell J, Ingram J, Hensley A, Zappia I, Newmark S, Gehn E, Rubin R A, Mitchell K, Bradstreet J, El-Dahr J M
机构信息
Division of Basic Medical Sciences, Southwest College of Naturopathic Medicine, Tempe, AZ 85282, USA.
出版信息
J Toxicol. 2009;2009:532640. doi: 10.1155/2009/532640. Epub 2009 Aug 26.
This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3-8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R(2) of 0.22-0.45, P < .005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.
本研究调查了儿童自闭症症状与其体内有毒金属负荷及红细胞（RBC）谷胱甘肽水平之间的关系。在3至8岁的儿童中，使用四种工具评估自闭症的严重程度：孤独症诊断观察量表（ADOS）、广泛性发育障碍行为量表（PDD - BI）、儿童自闭症评定量表（ATEC）和社交适应量表（SAS）。通过测量口服二巯基丁二酸（DMSA）前后有毒金属的尿排泄量来评估有毒金属的身体负担。在自闭症严重程度与有毒金属的尿排泄量之间发现了多个正相关。自闭症测量严重程度的变化部分可以通过对DMSA前后有毒金属的尿排泄量以及RBC谷胱甘肽水平的回归分析来解释（所有情况下调整后的R²为0.22 - 0.45，P <.005）。本研究表明自闭症严重程度与有毒金属的相对身体负担之间存在显著正相关。
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