Adams James B, Baral Matthew, Geis Elizabeth, Mitchell Jessica, Ingram Julie, Hensley Andrea, Zappia Irene, Newmark Sanford, Gehn Eva, Rubin Robert A, Mitchell Ken, Bradstreet Jeff, El-Dahr Jane
Division of Basic Medical Sciences, Southwest College of Naturopathic Medicine, Tempe, AZ, USA.
BMC Clin Pharmacol. 2009 Oct 23;9:17. doi: 10.1186/1472-6904-9-17.
This study investigated the effects of oral dimercapto succinic acid (DMSA) therapy on the behavioural symptoms of children with autism spectrum disorders (ASD) ages 3-8 years.
Phase 1 involved 65 children with ASD who received one round of DMSA (3 days). Participants who had high urinary excretion of toxic metals were selected to continue on to phase 2. In phase 2, 49 participants were randomly assigned in a double-blind design to receive an additional 6 rounds of either DMSA or placebo.
The groups receiving one round and seven rounds of DMSA had significant improvements on all the assessment measures. For the seven round group, the degree of improvement on the assessment measures could be partially explained by a regression analysis based on excretion of toxic metals and changes in glutathione (adjusted R2 of 0.28-0.75, p < 0.02 in all cases). One round of DMSA had nearly the same benefit as seven rounds. The assessment measures correlated reasonably with one another at the beginning of the study (r = 0.60-0.87) and even better at the end of the study (r = 0.63-0.94).
Overall, both one and seven rounds of DMSA therapy seems to be reasonably safe in children with ASD who have high urinary excretion of toxic metals, and possibly helpful in reducing some of the symptoms of autism in those children.
本研究调查了口服二巯基丁二酸（DMSA）疗法对3至8岁自闭症谱系障碍（ASD）儿童行为症状的影响。
第一阶段涉及65名接受一轮DMSA治疗（3天）的ASD儿童。选择有毒金属尿排泄量高的参与者继续进入第二阶段。在第二阶段，49名参与者以双盲设计随机分配，接受另外6轮DMSA或安慰剂治疗。
接受一轮和七轮DMSA治疗的组在所有评估指标上都有显著改善。对于七轮治疗组，评估指标的改善程度可以通过基于有毒金属排泄和谷胱甘肽变化的回归分析部分解释（调整后的R2为0.28 - 0.75，所有情况下p < 0.02）。一轮DMSA的益处与七轮几乎相同。在研究开始时，评估指标之间的相关性合理（r = 0.60 - 0.87），在研究结束时相关性更好（r = 0.63 - 0.94）。
总体而言，对于有毒金属尿排泄量高的ASD儿童，一轮和七轮DMSA治疗似乎都相当安全，并且可能有助于减轻这些儿童的一些自闭症症状。
