通过光谱光学相干断层扫描对切除的人类乳腺癌中的金纳米棒进行成像。
Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography.
作者信息
Oldenburg Amy L, Hansen Matthew N, Ralston Tyler S, Wei Alexander, Boppart Stephen A
机构信息
Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. Tel: +1 (217) 244-7479.
出版信息
J Mater Chem. 2009 Jan 1;19:6407. doi: 10.1039/b823389f.
Abstract
Plasmon-resonant gold nanorods (GNRs) can serve as imaging agents for spectroscopic optical coherence tomography (SOCT). The aspect ratio of the GNRs are adjusted for maximum absorption in the far red to create a partial spectral overlap with the low-wavelength edge of the near-infrared SOCT imaging band. The spectroscopic absorption profile of the GNRs is incorporated into a depth-resolved algorithm for mapping the relative GNR density within OCT images. This technique enables us to image GNR distributions in excised human breast carcinomas, demonstrating their potential as OCT contrast agents in heteregeneous, highly scattering tissues.
摘要
等离子体共振金纳米棒（GNRs）可作为光谱光学相干断层扫描（SOCT）的成像剂。调整GNRs的纵横比，使其在远红外区域具有最大吸收，从而与近红外SOCT成像波段的低波长边缘产生部分光谱重叠。将GNRs的光谱吸收轮廓纳入深度分辨算法，以绘制OCT图像内相对GNR密度图。该技术使我们能够对切除的人类乳腺癌中的GNR分布进行成像，证明了它们作为OCT造影剂在异质、高散射组织中的潜力。
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