Departamento de Quimica-Fisica and Unidad Asociada CSIC-Universidade de Vigo 36310 Vigo, Spain.
Small. 2010 Mar 8;6(5):604-10. doi: 10.1002/smll.200901820.
Surface-enhanced Raman scattering (SERS) spectroscopy is one of the most powerful analytical techniques for identification of molecular species, with the potential to reach single-molecule detection under ambient conditions. This Concept article presents a brief introduction and discussion of both recent advances and limitations of SERS in the context of diagnosis and biodetection, ranging from direct sensing to the use of encoded nanoparticles, in particular focusing on ultradetection of relevant bioanalytes, rapid diagnosis of diseases, marking of organelles within individual cells, and non-invasive tagging of anomalous tissues in living animals.
表面增强拉曼散射（SERS）光谱学是用于识别分子种类的最强大的分析技术之一，在环境条件下具有达到单分子检测的潜力。本文简要介绍和讨论了 SERS 在诊断和生物检测方面的最新进展和局限性，从直接传感到编码纳米粒子的使用，特别关注相关生物分析物的超高检测、疾病的快速诊断、单个细胞内细胞器的标记以及活体动物中异常组织的非侵入性标记。
