来自软珊瑚 Plumigorgia terminosclera 的新型骨架二萜化合物 Plumisclerin A。

Plumisclerin A, a diterpene with a new skeleton from the soft coral Plumigorgia terminosclera.

机构信息

Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte, Avda. de los Reyes 1, 28770 Colmenar Viejo (Madrid), Spain.

出版信息

Org Lett. 2010 Mar 5;12(5):912-4. doi: 10.1021/ol902802h.

DOI:10.1021/ol902802h

PMID:20108913

Abstract

A novel compound, named plumisclerin A (1), was isolated from samples of the soft coral Plumigorgia terminosclera collected at Mayotte Island. The compound possesses the novel plumisclerane carbon skeleton, including a tricyclo[4,3,1,0(1,5)]decane ring. Its structure and relative stereochemistry were elucidated by extensive spectroscopic analysis, including HREIMS, COSY, HSQC, HMBC, TOCSY, and NOESY experiments. In addition, the novel compound displayed in vitro cytotoxicity against selected cancer cell lines.

摘要

一种新型化合物，命名为 plumisclerin A（1），从在马约特岛采集的软珊瑚 Plumigorgia terminosclera 样品中分离得到。该化合物具有新颖的 plumisclerane 碳骨架，包括三环[4,3,1,0（1,5）]癸烷环。其结构和相对立体化学通过广泛的光谱分析，包括 HREIMS、COSY、HSQC、HMBC、TOCSY 和 NOESY 实验来阐明。此外，该新型化合物对选定的癌细胞系表现出体外细胞毒性。