Duh Chang-Yih, Li Chia-Hua, Wang Shang-Kwei, Dai Chang-Feng
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
J Nat Prod. 2006 Aug;69(8):1188-92. doi: 10.1021/np0505465.
Four new cespitularane diterpenes, cesputularins I-L (1-4), two new norverticillane norditerpenes, cespitularins M and N (5 and 6), two new verticillane diterpenes, cespitularins O and P (7 and 8), a new norditerpene, cespitularin Q (9) (having a novel carbon skeleton), a new xenicane diterpene, cespitolide (10), and two new secosteroids, 3beta,11-dihydroxy-5beta,6beta-epoxy-9,11-secocholestan-9-one (11) and 3beta,11-dihydroxy-5beta,6beta-epoxy-9,11-secogorgostan-9-one (12), were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata Roxas. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
从台湾软珊瑚Cespitularia hypotentaculata Roxas的二氯甲烷可溶物中分离出4个新的丛生烷二萜类化合物，即丛生珊瑚素I-L（1-4），2个新的降维蒂西烷降二萜类化合物，丛生珊瑚素M和N（5和6），2个新的维蒂西烷二萜类化合物，丛生珊瑚素O和P（7和8），1个新的降二萜类化合物，丛生珊瑚素Q（9）（具有新颖的碳骨架），1个新的异香豆烷二萜类化合物，丛生内酯（10），以及2个新的甾体化合物，3β,11-二羟基-5β,6β-环氧-9,11-断胆甾烷-9-酮（11）和3β,11-二羟基-5β,6β-环氧-9,11-断戈甾烷-9-酮（12）。通过广泛的光谱分析阐明了这些化合物的结构，并在体外测定了它们对选定癌细胞的细胞毒性。
