来自台湾软珊瑚Xenia blumi的异株二萜类化合物。
Xenia diterpenoids from the formosan soft coral Xenia blumi.
作者信息
El-Gamal Ali A H, Chiang Chin-Ying, Huang Shin-Huei, Wang Shang-Kwei, Duh Chang-Yih
机构信息
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
出版信息
J Nat Prod. 2005 Sep;68(9):1336-40. doi: 10.1021/np058047r.
Eight new xenia diterpenoids, blumiolide-A (1) (novel carbon skeleton), blumiolide-B (2), 9-deoxy-isoxeniolide-A (3), 9-deoxy-7,8-epoxy-isoxeniolide-A (4), 9-deacetoxy-7,8-epoxy-13-epi-xenicin (5), 9-deoxy-7,8-epoxy-xeniolide-A (6), blumiolide-C (7), and blumicin-A (8), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia blumi. Their structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
从台湾软珊瑚Xenia blumi的二氯甲烷可溶物中分离出8种新的异株克生二萜类化合物，即布鲁米内酯-A（1）（新型碳骨架）、布鲁米内酯-B（2）、9-脱氧异株克生内酯-A（3）、9-脱氧-7,8-环氧异株克生内酯-A（4）、9-脱乙酰氧基-7,8-环氧-13-表异株克生素（5）、9-脱氧-7,8-环氧异株克生内酯-A（6）、布鲁米内酯-C（7）和布鲁米星-A（8）。通过广泛的光谱分析阐明了它们的结构，并在体外测定了它们对选定癌细胞的细胞毒性。
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