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本文引用的文献

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Targeting proteins for degradation.靶向蛋白质降解。
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2
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa.结核分枝杆菌蛋白酶体 ATP 酶 Mpa 的结构见解。
Structure. 2009 Oct 14;17(10):1377-85. doi: 10.1016/j.str.2009.08.010.
3
A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa.原核生物类泛素蛋白（Pup）的一个独特结构区域被蛋白酶体ATP酶Mpa的N端结构域识别。
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Breaking the chains: structure and function of the deubiquitinases.挣脱枷锁：去泛素化酶的结构与功能
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5
Prokaryotic ubiquitin-like protein pup is intrinsically disordered.原核生物类泛素蛋白pup本质上是无序的。
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6
Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein.Pup是一种原核生物类泛素蛋白，是一种内在无序蛋白。
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7
Recognition and processing of ubiquitin-protein conjugates by the proteasome.蛋白酶体对泛素-蛋白质缀合物的识别与加工。
Annu Rev Biochem. 2009;78:477-513. doi: 10.1146/annurev.biochem.78.081507.101607.
8
RING domain E3 ubiquitin ligases.环状结构域E3泛素连接酶
Annu Rev Biochem. 2009;78:399-434. doi: 10.1146/annurev.biochem.78.101807.093809.
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Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.泛素特异性去泛素化酶的调控及其细胞作用
Annu Rev Biochem. 2009;78:363-97. doi: 10.1146/annurev.biochem.78.082307.091526.
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Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis.原核生物类泛素蛋白（Pup）、蛋白酶体与发病机制。
Nat Rev Microbiol. 2009 Jul;7(7):485-91. doi: 10.1038/nrmicro2148. Epub 2009 Jun 1.

泛素化与多聚泛素化：蛋白酶体依赖性降解的标记。

Pupylation versus ubiquitylation: tagging for proteasome-dependent degradation.

机构信息

Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.

出版信息

Cell Microbiol. 2010 Apr 1;12(4):424-31. doi: 10.1111/j.1462-5822.2010.01447.x. Epub 2010 Jan 26.

DOI:10.1111/j.1462-5822.2010.01447.x
PMID:20109157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3647454/
Abstract

Prokaryotic ubiquitin-like protein (Pup) is the first identified prokaryotic protein that is functionally analogous to ubiquitin. Despite using the proteasome as the end-point for proteolysis, Pup differs from ubiquitin both biochemically and structurally. We will discuss these differences that have been highlighted by several recent studies. Finally, we will speculate on the possible interactions between the two analogous pathways in pathogen and host.

摘要

原核泛素样蛋白（Pup）是首个被鉴定出的在功能上与泛素类似的原核蛋白。尽管它使用蛋白酶体作为蛋白水解的终点，但 Pup 在生化和结构上与泛素都有所不同。我们将讨论这些差异，这些差异已被最近的几项研究强调。最后，我们将推测两种类似途径在病原体和宿主之间的可能相互作用。