泛素化与多聚泛素化：蛋白酶体依赖性降解的标记。
Pupylation versus ubiquitylation: tagging for proteasome-dependent degradation.
机构信息
Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Cell Microbiol. 2010 Apr 1;12(4):424-31. doi: 10.1111/j.1462-5822.2010.01447.x. Epub 2010 Jan 26.
Abstract
Prokaryotic ubiquitin-like protein (Pup) is the first identified prokaryotic protein that is functionally analogous to ubiquitin. Despite using the proteasome as the end-point for proteolysis, Pup differs from ubiquitin both biochemically and structurally. We will discuss these differences that have been highlighted by several recent studies. Finally, we will speculate on the possible interactions between the two analogous pathways in pathogen and host.
摘要
原核泛素样蛋白（Pup）是首个被鉴定出的在功能上与泛素类似的原核蛋白。尽管它使用蛋白酶体作为蛋白水解的终点，但 Pup 在生化和结构上与泛素都有所不同。我们将讨论这些差异，这些差异已被最近的几项研究强调。最后，我们将推测两种类似途径在病原体和宿主之间的可能相互作用。
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