Department of Psychology, Technische Universität Dresden, Dresden, Germany.
Neurosci Biobehav Rev. 2010 Sep;35(1):91-6. doi: 10.1016/j.neubiorev.2010.01.010. Epub 2010 Jan 28.
Cumulative acute psychosocial stress is thought to promote the development of a range of disorders which suggests that biomarkers for the physiological response may become valuable tools for biomedical research and development. The search for these biomarkers has been aided by the development of a standardised protocol for inducing psychosocial stress that combines social-evaluative threat and uncontrollability, i.e., the Trier Social Stress Test (TSST). Among other biological markers of acute stress, this test induces significant changes of the hypothalamus-pituitary-adrenal axis (HPAA), which is thought to play a pivotal role in the generation of stress-associated pathologies. The HPAA responses show differences between patients and healthy subjects as well as between pathologies. Moreover, gender, age, personality traits, social environment, and genotype can also shape the individual's acute stress response triggered by the TSST. Characterization of the roles and interactions of these factors in generating a dysregulation of the neuroendocrine responses to acute psychosocial stress await longitudinal studies.
累积性急性心理社会应激被认为会促进一系列疾病的发展，这表明生理反应的生物标志物可能成为生物医学研究和开发的有价值的工具。通过开发一种标准化的方案来诱导心理社会应激，该方案结合了社会评价威胁和不可控性，即特里尔社会应激测试（TSST），有助于寻找这些生物标志物。在急性应激的其他生物标志物中，该测试会引起下丘脑-垂体-肾上腺轴（HPAA）的显著变化，HPAA 被认为在应激相关病理的产生中起着关键作用。HPAA 反应在患者和健康受试者之间以及在不同的病理之间存在差异。此外，性别、年龄、个性特征、社会环境和基因型也可以塑造个体对 TSST 引发的急性应激反应。这些因素在产生神经内分泌对急性心理社会应激反应失调中的作用和相互作用的特征还需要进行纵向研究。
