Laboratory of Epidemiology, Veterinary Research Institute, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun 130062, PR China.
Virus Res. 2010 May;149(2):143-51. doi: 10.1016/j.virusres.2010.01.010. Epub 2010 Jan 28.
Rabies virus was isolated from the brain of a Chinese ferret badger (Melogale moschata) and identified as having an R333Q substitution within its glycoprotein antigenic site III. Additionally, compared with vaccine strains and other rabies virus isolates from dogs and ferret badgers in China, the isolate had five other amino acid substitutions in its glycoprotein: P(-17)L in the signal peptide, R88H, L225M, and D422E in the ectoplasmic region, and G478E in the cytoplasmic region. This isolate possessed high virulence in suckling, weanling and adult mice. These data indicate that this is a unique rabies virus with a molecular signature that differentiates it from other strains circulating in terrestrial mammals in China. We propose that rabies virus circulates in some ferret badgers in an independent epidemiological cycle unique to China following spillover from domestic dogs or other hosts infected with rabies.
狂犬病病毒从中国雪貂（Melogale moschata）的脑组织中分离出来，并确定其糖蛋白抗原位点 III 内存在 R333Q 取代。此外，与中国犬和雪貂中的疫苗株及其他狂犬病病毒分离株相比，该分离株的糖蛋白还存在另外五个氨基酸取代：信号肽中的 P(-17)L、外质区域的 R88H、L225M 和 D422E 以及细胞质区域的 G478E。该分离株在乳鼠、断乳鼠和成年鼠中具有高毒力。这些数据表明，这是一种独特的狂犬病病毒，其分子特征使其与中国流行的其他陆地哺乳动物中的其他毒株不同。我们提出，狂犬病病毒在中国从感染狂犬病的家犬或其他宿主溢出后，在一些雪貂中独立于其他宿主形成独特的流行病学循环。
