Chiou Hue-Ying, Hsieh Chia-Hung, Jeng Chian-Ren, Chan Fang-Tse, Wang Hurng-Yi, Pang Victor Fei
Emerg Infect Dis. 2014 May;20(5):790-8. doi: 10.3201/eid2005.131389.
After the last reported cases of rabies in a human in 1959 and a nonhuman animal in 1961, Taiwan was considered free from rabies. However, during 2012-2013, an outbreak occurred among ferret badgers in Taiwan. To examine the origin of this virus strain, we sequenced 3 complete genomes and acquired multiple rabies virus (RABV) nucleoprotein and glycoprotein sequences. Phylogeographic analyses demonstrated that the RABV affecting the Taiwan ferret badgers (RABV-TWFB) is a distinct lineage within the group of lineages from Asia and that it has been differentiated from its closest lineages, China I (including isolates from Chinese ferret badgers) and the Philippines, 158-210 years ago. The most recent common ancestor of RABV-TWFB originated 91-113 years ago. Our findings indicate that RABV could be cryptically circulating in the environment. An understanding of the underlying mechanism might shed light on the complex interaction between RABV and its host.
在1959年最后一例人类狂犬病报告病例以及1961年最后一例非人类动物狂犬病报告病例之后，台湾被认为已无狂犬病。然而，在2012 - 2013年期间，台湾的鼬獾中爆发了狂犬病疫情。为了研究该病毒株的起源，我们对3个完整基因组进行了测序，并获取了多个狂犬病病毒（RABV）核蛋白和糖蛋白序列。系统发育地理学分析表明，影响台湾鼬獾的狂犬病病毒（RABV - TWFB）是亚洲谱系组内的一个独特谱系，并且它在158 - 210年前就已与其最接近的谱系，即中国I（包括来自中华鼬獾的分离株）和菲律宾谱系分化。RABV - TWFB的最近共同祖先起源于91 - 113年前。我们的研究结果表明，狂犬病病毒可能在环境中隐匿传播。对其潜在机制的了解可能有助于揭示狂犬病病毒与其宿主之间的复杂相互作用。
