真核细胞纺锤体组装和维持中的微管马达。
Microtubule motors in eukaryotic spindle assembly and maintenance.
机构信息
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, United States.
出版信息
Semin Cell Dev Biol. 2010 May;21(3):248-54. doi: 10.1016/j.semcdb.2010.01.015. Epub 2010 Jan 28.
Abstract
The spindle is a microtubule-based structure that facilitates chromosome segregation during mitosis and meiosis. Spindle assembly from dynamic microtubule building blocks is a major challenge for the dividing cell and a process that critically requires microtubule motors. In this review we focus on the mechanisms by which microtubule motors shape the spindle. Specifically, we address how motors are thought to move and arrange microtubules to form the characteristic bipolar morphology shared by all eukaryotic spindles as well as motor-dependent mechanisms of microtubule length regulation.
摘要
纺锤体是一种基于微管的结构，它在有丝分裂和减数分裂过程中促进染色体分离。纺锤体由动态微管构建块组装而成，这对正在分裂的细胞来说是一个重大挑战，这个过程对微管马达的依赖性极高。在这篇综述中，我们重点关注微管马达塑造纺锤体的机制。具体来说，我们讨论了马达是如何移动和排列微管以形成所有真核纺锤体所共有的特征双极形态的，以及马达依赖的微管长度调节机制。
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