Medical Science Program, Indiana University, Bloomington, IN 47405, USA.
Semin Cell Dev Biol. 2010 May;21(3):276-82. doi: 10.1016/j.semcdb.2010.01.016. Epub 2010 Jan 28.
Dynamic microtubules are essential for the process of mitosis. Thus, elucidating when, where, and how microtubule dynamics are regulated is key to understanding this process. One important class of proteins that directly regulates microtubule dynamics is the Kinesin-13 family. Kinesin-13 proteins induce depolymerization uniquely from both ends of the microtubule. This activity coincides with their cellular localization and with their ability to regulate microtubule dynamics to control spindle assembly and kinetochore-microtubule attachments. In this review, we highlight recent findings that dissect the important actions of Kinesin-13 family members and summarize important studies on the regulation of their activity by phosphorylation and by protein-protein interactions.
动态微管对于有丝分裂过程是必不可少的。因此，阐明微管动力学何时、何地以及如何受到调节对于理解这一过程至关重要。一类能够直接调节微管动力学的重要蛋白质是驱动蛋白-13 家族。驱动蛋白-13 蛋白能够从微管的两端诱导解聚。这种活性与其细胞定位以及调节微管动力学以控制纺锤体组装和动粒-微管连接的能力相一致。在这篇综述中，我们强调了最近的发现，这些发现剖析了驱动蛋白-13 家族成员的重要作用，并总结了关于其磷酸化和蛋白-蛋白相互作用调节其活性的重要研究。
