Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Med Sci Monit. 2010 Feb;16(2):CR92-5.
In recent years several studies showed an association between body iron stores, represented by serum ferritin, and oxidative stress. The pathophysiological mechanism of hypertensive retinopathy (HR) is not fully established. Elevated blood pressure alone does not fully account for the extent of retinopathy; other pathogenic mechanisms may be involved, such as increased oxidative stress. Therefore this study was designed to determine whether ferritin levels change in HR and whether there is any relationship between the degree of HR and ferritin level.
MATERIAL/METHODS: This study included 72 essential hypertensive patients with HR. The hypertensive patients were divided into two groups according to the Keith-Wagener classification. Group 1 comprised 36 patients with grade I HR and group 2 36 patients with grade II HR Thirty-six normotensive healthy subjects matched for age, sex, and body mass index were selected for the control group.
The level of ferritin in group 2 was significantly higher than in group 1 (92.9+/-31.8 vs. 77.8+/-23.7 ng/ml, p=0.027) and the normotensive control group (92.9+/-31.8 vs. 59.9+/-19.2 ng/ml, p=0.001). It was also higher in group 2 than in the control group (77.8+/-23.7 vs. 59.9+/-19.2 ng/ml, p=0.018). Ferritin level also showed positive correlation with the degree of HR in the hypertensive group (r=0.31, p=0.026).
This study suggests that there is a relationship between HR and ferritin level, which may be associated with an increased level of oxidative stress.
近年来，多项研究表明血清铁蛋白代表的体内铁储存与氧化应激之间存在关联。高血压性视网膜病变（HR）的病理生理机制尚未完全确立。单纯的血压升高并不能完全解释视网膜病变的程度；可能涉及其他致病机制，如氧化应激增加。因此，本研究旨在确定 HR 患者的铁蛋白水平是否发生变化，以及 HR 程度与铁蛋白水平之间是否存在任何关系。
材料/方法：本研究纳入 72 例 HR 的原发性高血压患者。根据 Keith-Wagener 分类，将高血压患者分为两组。第 1 组 36 例为 I 级 HR，第 2 组 36 例为 II 级 HR。选择 36 名年龄、性别和体重指数匹配的血压正常的健康受试者作为对照组。
第 2 组的铁蛋白水平明显高于第 1 组（92.9+/-31.8 与 77.8+/-23.7ng/ml，p=0.027）和血压正常的对照组（92.9+/-31.8 与 59.9+/-19.2ng/ml，p=0.001）。与对照组相比，第 2 组的铁蛋白水平也更高（77.8+/-23.7 与 59.9+/-19.2ng/ml，p=0.018）。在高血压组中，铁蛋白水平与 HR 程度呈正相关（r=0.31，p=0.026）。
本研究表明 HR 与铁蛋白水平之间存在关联，这可能与氧化应激水平增加有关。
