着丝粒组装与传播。

Centromere assembly and propagation.

作者信息

Morris Corey A, Moazed Danesh

机构信息

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Cell. 2007 Feb 23;128(4):647-50. doi: 10.1016/j.cell.2007.02.002.

DOI:10.1016/j.cell.2007.02.002

PMID:17320502

Abstract

Centromere assembly provides a unique example of how elaborate protein structures can be assembled onto DNA, independent of sequence, and then stably propagated through numerous cell divisions. Here, we review the possible epigenetic strategies that organisms ranging from yeast to human use to assemble and propagate active centromeres.

摘要

着丝粒组装提供了一个独特的例子，展示了复杂的蛋白质结构如何在不依赖序列的情况下组装到DNA上，然后通过多次细胞分裂稳定地遗传下去。在这里，我们回顾了从酵母到人类的各种生物体用于组装和遗传活性着丝粒的可能的表观遗传策略。