Popken G
HELIOS-Kliniken Berlin Buch, Schwanebecker Chaussee 50, 13125, Berlin, Deutschland.
Urologe A. 2010 Jan;49(1):37-42. doi: 10.1007/s00120-009-2196-9.
Male hypogonadism is based on an insufficient gonadal function, especially testosterone deficiency. The decreased endogenous production of testosterone can be acquired or congenital. The lack of testosterone results in typical clinical symptoms which give initial indications for testosterone replacement therapy. Nevertheless, less than 10% of the affected patients receive an adequate treatment. Presently different preparations and application forms are available for the therapy of hypogonadism with testosterone. Intramuscular, peroral, transdermal, sublingual and subcutaneous preparations show differences in pharmacodynamics, pharmacokinetics, price and handling. Therefore these formulations should be applied individually. Regular clinical and chemical controls of effect, side effects and contraindications are essential along with long-term substitution.
男性性腺功能减退是基于性腺功能不足，尤其是睾酮缺乏。内源性睾酮分泌减少可能是后天获得性的或先天性的。睾酮缺乏会导致典型的临床症状，这些症状为睾酮替代疗法提供了初步指征。然而，不到10%的受影响患者接受了充分的治疗。目前有不同的制剂和应用形式可用于睾酮治疗性腺功能减退。肌肉注射、口服、透皮、舌下和皮下制剂在药效学、药代动力学、价格和使用方面存在差异。因此，这些制剂应个体化应用。在长期替代治疗过程中，定期进行临床和化学检查以评估疗效、副作用和禁忌证至关重要。
