阿达木单抗和帕米膦酸二钠联合治疗强直性脊柱炎患者的疗效。

The synergistic efficacy of adalimumab and pamidronate in a patient with ankylosing spondylitis.

机构信息

Department of Internal Medicine A, Bnai Zion Medical Center, Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa, 31048, PO Box 4940, Israel.

出版信息

Clin Rheumatol. 2010 Jul;29(7):793-4. doi: 10.1007/s10067-010-1378-6. Epub 2010 Jan 29.

DOI:10.1007/s10067-010-1378-6

PMID:20111975

Abstract

A patient with ankylosing spondylitis, after demonstrating incomplete clinical response to adalimumab, received three monthly infusions of pamidronate along with continuing TNF-alpha blockade. Complete disappearance of the back pain was reported after the second pamidronate infusion. The perspectives of the combination therapy with TNF-alpha inhibitor and pamidronate are discussed.

摘要

一位强直性脊柱炎患者在阿达木单抗治疗后显示不完全临床应答，在继续接受 TNF-α 阻断治疗的同时接受了三次帕米膦酸盐每月输注。第二次输注帕米膦酸盐后，背痛完全消失。讨论了 TNF-α 抑制剂和帕米膦酸盐联合治疗的前景。