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阿达木单抗和帕米膦酸二钠联合治疗强直性脊柱炎患者的疗效。

The synergistic efficacy of adalimumab and pamidronate in a patient with ankylosing spondylitis.

机构信息

Department of Internal Medicine A, Bnai Zion Medical Center, Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa, 31048, PO Box 4940, Israel.

出版信息

Clin Rheumatol. 2010 Jul;29(7):793-4. doi: 10.1007/s10067-010-1378-6. Epub 2010 Jan 29.

DOI:10.1007/s10067-010-1378-6
PMID:20111975
Abstract

A patient with ankylosing spondylitis, after demonstrating incomplete clinical response to adalimumab, received three monthly infusions of pamidronate along with continuing TNF-alpha blockade. Complete disappearance of the back pain was reported after the second pamidronate infusion. The perspectives of the combination therapy with TNF-alpha inhibitor and pamidronate are discussed.

摘要

一位强直性脊柱炎患者在阿达木单抗治疗后显示不完全临床应答，在继续接受 TNF-α 阻断治疗的同时接受了三次帕米膦酸盐每月输注。第二次输注帕米膦酸盐后，背痛完全消失。讨论了 TNF-α 抑制剂和帕米膦酸盐联合治疗的前景。

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1
The synergistic efficacy of adalimumab and pamidronate in a patient with ankylosing spondylitis.阿达木单抗和帕米膦酸二钠联合治疗强直性脊柱炎患者的疗效。
Clin Rheumatol. 2010 Jul;29(7):793-4. doi: 10.1007/s10067-010-1378-6. Epub 2010 Jan 29.
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本文引用的文献

1
A systematic MEDLINE analysis of therapeutic approaches in ankylosing spondylitis.一项关于强直性脊柱炎治疗方法的MEDLINE系统分析。
Rheumatol Int. 2009 Aug;29(10):1123-35. doi: 10.1007/s00296-009-0973-9. Epub 2009 Jun 28.
2
Efficacy and safety of adalimumab in patients with ankylosing spondylitis: results of a multicenter, randomized, double-blind, placebo-controlled trial.阿达木单抗治疗强直性脊柱炎患者的疗效和安全性：一项多中心、随机、双盲、安慰剂对照试验的结果
Arthritis Rheum. 2006 Jul;54(7):2136-46. doi: 10.1002/art.21913.
3
Efficacy and safety of infliximab in patients with ankylosing spondylitis: results of a randomized, placebo-controlled trial (ASSERT).
英夫利昔单抗治疗强直性脊柱炎患者的疗效与安全性：一项随机、安慰剂对照试验（ASSERT）的结果
Arthritis Rheum. 2005 Feb;52(2):582-91. doi: 10.1002/art.20852.
4
Six-month results of a double-blind, placebo-controlled trial of etanercept treatment in patients with active ankylosing spondylitis.依那西普治疗活动性强直性脊柱炎患者的双盲、安慰剂对照试验的六个月结果。
Arthritis Rheum. 2003 Jun;48(6):1667-75. doi: 10.1002/art.11017.
5
A six-month randomized, controlled, double-blind, dose-response comparison of intravenous pamidronate (60 mg versus 10 mg) in the treatment of nonsteroidal antiinflammatory drug-refractory ankylosing spondylitis.静脉注射帕米膦酸二钠（60毫克与10毫克）治疗非甾体抗炎药难治性强直性脊柱炎的六个月随机、对照、双盲、剂量反应比较。
Arthritis Rheum. 2002 Mar;46(3):766-73. doi: 10.1002/art.10139.