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巴雷特食管的治疗。

The treatment of Barrett's esophagus.

作者信息

Hoara Petre, Gindea Cristina, Birla Rodica, Mocanu Adrian, Tavlas Emmanouil, Constantinoiu Silviu

机构信息

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

出版信息

J Med Life. 2009 Jul-Sep;2(3):241-8.

Abstract

The reflux of the gastric juice in the esophagus can determine the injury of the esophageal epithelium. When the healing of the lesion is done by replacing the normal squamous epithelium with columnar epithelium, the entity is called Barrett's esophagus (BE). Although controversial, some studies showed 0,5% per year the incidence of the esophageal adenocarcinoma in patients with BE, 30 times more often than general population. Taking into consideration the possible development of an adenocarcinoma, the patients with Barrett's esophagus require endoscopic surveillance after a standardized protocol. There is still much controversy about the treatment of patients with Barrett's esophagus, especially in the presence of dysplasia. The aims of the treatment are gastro-esophageal reflux symptoms control, healing of associated esophagitis and prevention of development of adenocarcinoma.

摘要

胃液反流至食管可导致食管上皮损伤。当病变愈合过程中正常鳞状上皮被柱状上皮取代时,这种情况被称为巴雷特食管(BE)。尽管存在争议,但一些研究表明,BE患者每年发生食管腺癌的发生率为0.5%,比普通人群高出30倍。鉴于可能发生腺癌,巴雷特食管患者需要按照标准化方案进行内镜监测。对于巴雷特食管患者的治疗,尤其是存在发育异常的情况,仍存在诸多争议。治疗的目的是控制胃食管反流症状、治愈相关食管炎并预防腺癌的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1efc/5052494/3db322433d0c/JMedLife-02-241-g001.jpg

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