Yoshid Fumiko, Okamoto Norio, Hosotani Yuka, Ueda Yoshiko, Kaida Katsuji, Ogawa Hiroyasu, Mimura Osamu
Department of Ophthalmology, Hyogo College of Medicine, Hyogo-ken, Japan.
Nippon Ganka Gakkai Zasshi. 2010 Jan;114(1):28-33.
A case of acute lymphoblastic leukemia in which a variety of ophthalmic findings were observed.
A 27-year-old woman with acute lymphoblastic leukemia. Ocular findings were Roth's spot and serous retinal detachment. Fluorescein angiography revealed no clear leak point. Subsequently, the serous retinal detachment disappeared. Within 4 months after the initial diagnosis, cytomegalovirus (CMV) retinitis occurred, and further keratoconjunctivitis and serous retinal detachment recurred due to Graft-versus-Host Disease (GVHD), thus resulting in death 4 months later.
Cases in which patients with leukemia complicated by serous retinal detachment during the course often result in death. In the present case, CMV retinitis and keratoconjunctivitis occurred due to GVHD after serous retinal detachment, thus resulting in death 8 months after the initial diagnosis, therefore if serous retinal detachment is observed in a leukemia patient, it is necessary to perform periodical ophthalmologic examinations even after the ocular symptoms disappear.
报告一例观察到多种眼科表现的急性淋巴细胞白血病病例。
一名27岁急性淋巴细胞白血病女性患者。眼部表现为 Roth 斑和浆液性视网膜脱离。荧光素血管造影未发现明确的渗漏点。随后，浆液性视网膜脱离消失。在初次诊断后4个月内，发生了巨细胞病毒（CMV）视网膜炎，并且由于移植物抗宿主病（GVHD）再次出现了角膜炎和浆液性视网膜脱离，最终在4个月后死亡。
白血病患者病程中并发浆液性视网膜脱离的病例通常会导致死亡。在本病例中，浆液性视网膜脱离后因GVHD发生了CMV视网膜炎和角膜炎，最终在初次诊断后8个月死亡，因此，如果在白血病患者中观察到浆液性视网膜脱离，即使眼部症状消失后也有必要定期进行眼科检查。
