急性淋巴细胞白血病复发表现为浆液性视网膜脱离和视盘肿胀。
Recurrence of acute lymphoblastic leukemia manifesting as serous retinal detachments and optic disc swelling.
作者信息
Yabas Kiziloglu Ozge, Mestanoglu Mert, Totuk Gedar Ozgun Melike, Adiguzel Cafer, Toygar Okan
机构信息
Department of Ophthalmology, Faculty of Medicine, Göztepe Medical Park Hospital, Bahcesehir University, E-5 uzeri 23 Nisan sok No: 17 Merdivenkoy, Kadikoy, Istanbul, Turkey.
Faculty of Medicine, Bahcesehir University, Istanbul, Turkey.
出版信息
Int Ophthalmol. 2018 Aug;38(4):1791-1795. doi: 10.1007/s10792-017-0648-6. Epub 2017 Jul 15.
PURPOSE
The aim of this case report is to describe a patient with acute lymphoblastic leukemia (ALL) who developed bilateral serous retinal detachments and unilateral optic disc swelling.
METHODS
A 23-year-old woman with ALL presented to the ophthalmology clinic with bilateral subacute visual loss.
RESULTS
Ophthalmologic examination revealed bilateral serous retinal detachments and unilateral optic disc swelling. Magnetic resonance imaging for differential diagnosis was inconclusive; however, cerebrospinal fluid sampling demonstrated leukemic involvement of the central nervous system. The patient's vision improved and fundus findings resolved with the institution of systemic and intrathecal chemotherapy.
CONCLUSIONS
Serous retinal detachment and optic disc swelling are unusual ocular manifestations of ALL. They may occur due to leukemic infiltration of ocular structures and may indicate extramedullary recurrence of the disease. Early recognition and treatment is crucial to improve prognosis.
目的
本病例报告旨在描述一名急性淋巴细胞白血病（ALL）患者，该患者出现双侧浆液性视网膜脱离和单侧视盘肿胀。
方法
一名患有ALL的23岁女性因双侧亚急性视力丧失就诊于眼科诊所。
结果
眼科检查发现双侧浆液性视网膜脱离和单侧视盘肿胀。用于鉴别诊断的磁共振成像结果不明确；然而，脑脊液采样显示中枢神经系统有白血病浸润。随着全身和鞘内化疗的开展，患者视力改善，眼底表现消退。
结论
浆液性视网膜脱离和视盘肿胀是ALL不常见的眼部表现。它们可能由于白血病浸润眼部结构而发生，可能提示疾病的髓外复发。早期识别和治疗对于改善预后至关重要。
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