Pathology Queensland, Brisbane, Queensland, Australia.
Emerg Infect Dis. 2010 Feb;16(2):219-23. doi: 10.3201/eid1602.090552.
A recent Hendra virus outbreak at a veterinary clinic in Brisbane, Queensland, Australia, involved 5 equine and 2 human infections. In contrast to previous outbreaks, infected horses had predominantly encephalitic, rather than respiratory, signs. After an incubation period of 9-16 days, influenza-like illnesses developed in the 2 persons before progressing to encephalitis; 1 died. Both patients were given ribavirin. Basal serum and cerebrospinal fluid levels were 10-13 mg/L after intravenous administration and 6 mg/L after oral administration (isolate 90% inhibitory concentration 64 mg/L). Both patients were exposed to infected horses, 1 during the late incubation period in a horse. The attack rate for veterinary clinic staff exposed to infected horses was 10%. An isolate from this outbreak showed genetic heterogeneity with isolates from a concurrent, but geographically remote, outbreak and from previous outbreaks. Emergence of Hendra virus is a serious medical, veterinary, and public health challenge.
最近在澳大利亚昆士兰州布里斯班的一家兽医诊所爆发了亨德拉病毒，涉及 5 匹马和 2 人感染。与以前的爆发不同，感染的马匹主要表现出脑炎，而不是呼吸道症状。在潜伏期 9-16 天后，2 名患者出现流感样疾病，随后发展为脑炎；其中 1 人死亡。两名患者均给予利巴韦林治疗。静脉给药后血清和脑脊液基础水平分别为 10-13 毫克/升，口服后为 6 毫克/升（分离株 90%抑制浓度为 64 毫克/升）。两名患者都接触过感染的马匹，其中 1 人在马的潜伏期后期接触过。接触感染马匹的兽医诊所工作人员的发病率为 10%。从这次爆发中分离出的病毒与同时发生但地理位置偏远的爆发以及以前爆发的病毒株存在遗传异质性。亨德拉病毒的出现是一个严重的医学、兽医和公共卫生挑战。
