Markarian Nathan M, Abrahamyan Levon
Faculté de Pharmacie, Université de Montréal, Montréal, QC, Canada.
Laboratory of Animal Molecular Virology, Swine and Poultry Infectious Diseases Research Center (CRIPA) and Research Group on Infectious Diseases in Production Animals (GREMIP), Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada.
Front Microbiol. 2024 Nov 1;15:1486792. doi: 10.3389/fmicb.2024.1486792. eCollection 2024.
The last 60 years have seen the emergence of several zoonotic viruses, some of which originate from bats. Among these are Nipah virus, Marburg virus and Ebola viruses, which have high case fatality rates, and pose significant public health risks. In 2012, another zoonotic paramyxovirus from bats, known as Sosuga Virus (SOSV), was discovered in a hospitalized biologist who had returned from a trip to Africa. Given the potential public health threats of the SOSV, investigating its pathogenesis, epidemiology and developing antiviral strategies are crucial to control possible future outbreaks. Thus, in this review, we explore the latest advancements in understanding SOSV since its discovery, focusing on its pathogenesis, animal models and the development of antiviral strategies. By examining the current literature, this review aims to provide a comprehensive overview to guide future studies and help public health efforts in better mitigating potential SOSV outbreaks.
在过去的60年里,出现了几种人畜共患病毒,其中一些起源于蝙蝠。这些病毒包括尼帕病毒、马尔堡病毒和埃博拉病毒,它们的病死率很高,对公共卫生构成重大风险。2012年,在一名从非洲旅行归来的住院生物学家身上发现了另一种来自蝙蝠的人畜共患副粘病毒,即索苏加病毒(SOSV)。鉴于SOSV对公共卫生的潜在威胁,研究其发病机制、流行病学并制定抗病毒策略对于控制未来可能的疫情爆发至关重要。因此,在本综述中,我们探讨了自SOSV发现以来在了解它方面的最新进展,重点关注其发病机制、动物模型和抗病毒策略的发展。通过研究当前的文献,本综述旨在提供一个全面的概述,以指导未来的研究,并帮助公共卫生工作更好地缓解潜在的SOSV疫情爆发。