Rubinstein M, Denays R, Ham H R, Piepsz A, VanPachterbeke T, Haumont D, Noël P
Department of Radioisotopes, St. Pierre Hospital, Brussels, Belgium.
J Nucl Med. 1989 Dec;30(12):1982-5.
The application of regional cerebral blood flow (rCBF) study by means of lipophilic radiotracers and single photon emission computed (SPECT) devices in very young infants is hampered by the considerable changes of rCBF pattern as a result of the cerebral maturation process. In an attempt to determine the normal evolution of [123I]IMP SPECT pattern as a function of age, we retrospectively selected the studies of 30 babies with normal clinical examination, EEG and CT or ultrasound scans at time of SPECT. There was a marked predominance of the thalamic perfusion over cortical areas until the end of the second month. The distribution of regional cortical activity followed a strict sequence. The perfusion of both parietal and occipital areas was well-visualized around the 40th week of gestational age and thereafter rapidly rose, always, however, with a slight predominance of the parietal activity. At the opposite, frontal activity which remained scarcely recognizable up to the second month tremendously rose to present the adult-like pattern at the beginning of the second year. The rCBF changes described above are well in agreement with the behavioral evolution occurring during prime infancy.
由于脑成熟过程导致的局部脑血流量（rCBF）模式的显著变化，利用亲脂性放射性示踪剂和单光子发射计算机断层扫描（SPECT）设备进行的rCBF研究在非常年幼的婴儿中的应用受到阻碍。为了确定[123I]IMP SPECT模式随年龄的正常演变，我们回顾性地选择了30例在进行SPECT检查时临床检查、脑电图和CT或超声扫描均正常的婴儿的研究。直到第二个月末，丘脑灌注明显高于皮质区域。区域皮质活动的分布遵循严格的顺序。顶叶和枕叶区域的灌注在孕40周左右清晰可见，此后迅速上升，但顶叶活动始终略有优势。相反，额叶活动在第二个月之前几乎无法识别，在第二年开始时急剧上升，呈现出类似成人的模式。上述rCBF变化与婴儿期早期发生的行为演变非常一致。
