Department of Pediatrics, Children's Hospital of The King's Daughters, Norfolk, VA, USA.
Early Hum Dev. 2010 Jul;86 Suppl 1(Suppl 1):7-12. doi: 10.1016/j.earlhumdev.2010.01.012. Epub 2010 Jan 29.
Late-onset sepsis in premature infants is a major cause of morbidity, mortality, and increased medical costs. Risk factors include low birth weight, low gestational age, previous antimicrobial exposure, poor hand hygiene, and central venous catheters. Methods studied to prevent late-onset sepsis include early feedings, immune globulin administration, prophylactic antimicrobial administration, and improved hand hygiene. In this review, we will outline the risk factors for development of late-onset sepsis and evidence supporting methods for prevention of late-onset sepsis in premature infants.
早产儿晚发性败血症是发病率、死亡率和医疗费用增加的主要原因。危险因素包括低出生体重、低胎龄、先前的抗菌药物暴露、手部卫生不良和中心静脉导管。研究预防晚发性败血症的方法包括早期喂养、免疫球蛋白给药、预防性抗菌药物给药和改善手部卫生。在这篇综述中，我们将概述早产儿发生晚发性败血症的危险因素和支持预防早产儿晚发性败血症方法的证据。
