Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, D.F., Mexico.
Steroids. 2010 Apr;75(4-5):346-9. doi: 10.1016/j.steroids.2010.01.014. Epub 2010 Jan 29.
Virginols A-C are three new withanolides containing an epoxylactol at the side chain. They were isolated from the aerial parts of Physalis virginiana Miller. Structures of these compounds were determined by analyses of their spectroscopic data, including 1D and 2D NMR. The structure of virginol A was confirmed by X-ray diffraction analysis. The anti-inflammatory activity of virginols was evaluated in the TPA-induced ear mouse edema model.
维生醇 A-C 是从灯笼草（Physalis virginiana Miller）的地上部分分离得到的三种新型含侧链环氧内酯的羽扇豆烷型三萜。通过分析其光谱数据，包括 1D 和 2D NMR，确定了这些化合物的结构。通过 X 射线衍射分析确定了维生醇 A 的结构。在 TPA 诱导的小鼠耳肿胀模型中评价了维生醇的抗炎活性。
