Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66045, United States.
J Nat Prod. 2014 Mar 28;77(3):631-9. doi: 10.1021/np400953n. Epub 2014 Jan 23.
Nine new withanolides (1-9), withahisolides A-I, were isolated along with nine known compounds (10-18) from the aerial parts of Physalis hispida. The structures of 1-9 were elucidated through a variety of spectroscopic techniques, while the structures of 1 and 2 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are the first withanolides with nonaromatic six-membered ring D moieties. In addition, withanolide 8 represents a novel withanolide skeleton due to the absence of a C-13-C-17 bond within the steroidal nucleus.
从酸浆属植物Physalis hispida 的地上部分分离得到了 9 个新的孕甾烷类化合物（1-9），包括 withahisolides A-I，以及另外 9 个已知化合物（10-18）。通过各种光谱技术阐明了 1-9 的结构，而 1 和 2 的结构则通过 X 射线晶体学分析得到了证实。化合物 1-3 是具有非芳香六元环 D 部分的第一个孕甾烷类化合物。此外，由于甾体核内不存在 C-13-C-17 键，化合物 8 代表了一种新型的孕甾烷骨架。
