佩利诺增强果蝇的固有免疫。

Pellino enhances innate immunity in Drosophila.

机构信息

Department of Biology, McGill University, 1205 Dr. Penfield Avenue, Montreal, Que., Canada H3A 1B1.

出版信息

Mech Dev. 2010 May-Jun;127(5-6):301-7. doi: 10.1016/j.mod.2010.01.004. Epub 2010 Feb 1.

DOI:10.1016/j.mod.2010.01.004

PMID:20117206

Abstract

The innate immune response is a defense mechanism against infectious agents in both vertebrates and invertebrates, and is in part mediated by the Toll pathway. Toll receptor activation upon exposure to bacteria causes stimulation of Pelle/IRAK kinase, eventually resulting in translocation of the transcription factor NF-kappaB to the nucleus. Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila.

摘要

先天免疫反应是脊椎动物和无脊椎动物抵御感染因子的一种防御机制，部分是通过 Toll 途径介导的。Toll 受体在接触细菌时被激活，导致 Pelle/IRAK 激酶的刺激，最终导致转录因子 NF-κB 向核内易位。在这里，我们表明与激活的 Pelle/IRAK 相互作用的高度保守蛋白 Pellino 在果蝇的先天免疫中起正向调节因子的作用。