Department of Occupational and Environmental Medicine (A2), Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba 260-8670, Japan.
Am J Prev Med. 2010 Feb;38(2):192-200. doi: 10.1016/j.amepre.2009.09.040.
Detailed information on the expected physiologic changes after smoking cessation is practically useful to encourage people to stop smoking. Furthermore, weight increase after cessation may affect such physiologic changes.
This article aims to evaluate the effect of smoking cessation on annual changes in body weight, blood pressure, and blood biochemistry.
This study analyzed the results of annual health examinations from 1991 to 2005 in male Japanese workers in 2009. Subjects classified as stopping smoking (n=445) responded initially as smokers in a self-administered questionnaire (baseline year) and then answered consistently as nonsmokers for 3 subsequent years. Of the 2672 smokers identified in the study, 2403 subjects who had data available for at least 4 successive years were selected as controls. The time course of physiologic and laboratory data was analyzed using a linear mixed model.
Data adjusted for age, type of job schedule, drinking and physical activity showed that subjects who stopped smoking had significantly greater increases in weight, BMI, systolic and diastolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, and uric acid and a greater decrease in hemoglobin in the 3 years following smoking cessation than continuing smokers. Additional adjustment for change in BMI from baseline negated the significant deterioration in systolic and diastolic blood pressure and total cholesterol that occurred following smoking cessation.
Increase in body weight, blood pressure, and blood biochemistry can continue for at least 3 years after smoking cessation. This study also indicated that these increases were related to the weight increase that occurred after smoking cessation.
详细了解戒烟后预期的生理变化对于鼓励人们戒烟非常有用。此外，戒烟后体重增加可能会影响这些生理变化。
本文旨在评估戒烟对体重、血压和血液生化的年度变化的影响。
本研究分析了 2009 年日本男性工人在 1991 年至 2005 年期间每年健康检查的结果。被归类为戒烟的受试者（n=445）在自我管理问卷中最初作为吸烟者回答（基线年），然后连续 3 年一致回答为非吸烟者。在研究中确定的 2672 名吸烟者中，选择了 2403 名至少有 4 年连续数据的吸烟者作为对照。使用线性混合模型分析生理和实验室数据的时间过程。
调整年龄、工作时间表类型、饮酒和体力活动后的数据表明，与继续吸烟的人相比，戒烟的人在戒烟后的 3 年内体重、BMI、收缩压和舒张压、总胆固醇、高密度脂蛋白胆固醇和尿酸显著增加，血红蛋白显著下降。进一步调整基线 BMI 的变化否定了戒烟后收缩压和总胆固醇显著恶化的情况。
体重、血压和血液生化的增加至少可以持续 3 年。本研究还表明，这些增加与戒烟后体重增加有关。
