Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Vet Pathol. 2010 Mar;47(2):312-7. doi: 10.1177/0300985809358605. Epub 2010 Jan 29.
Over the period of a year, colitis was observed in 44 mice raised in a conventional nonspecific pathogen-free colony, 41 of these having concomitant retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS). The lesions varied from bacterial colonization to hyperplasia of colonic mucosa to severe, often fatal, ulceration. Citrobacter rodentium was isolated from the colon and/or liver of 2 mice with colitis. When C57BL/6 mice with or without MAIDS were given graded doses of the bacterium, only those with MAIDS developed colitis, and C rodentium was reisolated from their livers. Thus, mice with MAIDS can develop severe disease following opportunistic infection with an environmental contaminant of the colony that is nonpathogenic for normal adult mice.
在一年的时间里，在一个常规的非特定病原体无菌群体中饲养的 44 只老鼠中观察到结肠炎，其中 41 只老鼠同时患有逆转录病毒诱导的获得性免疫缺陷综合征（MAIDS）。病变从细菌定植到结肠黏膜增生到严重的、常致命的溃疡不等。从 2 只有结肠炎的老鼠的结肠和/或肝脏中分离出了柠檬酸杆菌。当给予 C57BL/6 老鼠不同剂量的细菌时，只有那些患有 MAIDS 的老鼠发展为结肠炎，并且从它们的肝脏中重新分离出 C 杆状菌。因此，患有 MAIDS 的老鼠在机会性感染无菌群体中的环境污染物后可能会发展为严重疾病，而这种污染物对正常成年老鼠是无毒的。
