精神分裂症患者及其未受影响的兄弟姐妹的前额叶皮质脑回结构异常。
Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings.
机构信息
Department of Psychiatry (Box 8134), Washington University School of Medicine, 660 S. Euclid Ave, St Louis, MO 63110, USA.
出版信息
Br J Psychiatry. 2010 Feb;196(2):150-7. doi: 10.1192/bjp.bp.109.067314.
Abstract
BACKGROUND
The relatives of individuals with schizophrenia exhibit deficits of overall frontal lobe volume, consistent with a genetic contribution to these deficits.
AIMS
To quantify the structure of gyral-defined subregions of prefrontal cortex in individuals with schizophrenia and their siblings.
METHOD
Grey matter volume, cortical thickness, and surface area of the superior, middle and inferior frontal gyri were measured in participants with schizophrenia and their unaffected (non-psychotic) siblings (n = 26 pairs), and controls and their siblings (n = 40 pairs).
RESULTS
Grey matter volume was reduced in the middle and inferior frontal gyri of individuals with schizophrenia, relative to controls. However, only inferior frontal gyrus volume was also reduced in the unaffected siblings of those with schizophrenia, yielding a volume intermediate between their affected siblings and controls.
CONCLUSIONS
The structure of subregions of the prefrontal cortex may be differentially influenced by genetic factors in schizophrenia, with inferior frontal gyrus volume being most related to familial risk.
摘要
背景
精神分裂症患者的亲属存在整体额叶体积不足的情况，这与这些缺陷的遗传因素有关。
目的
定量分析精神分裂症患者及其同胞的额前皮质脑回定义的亚区的结构。
方法
在精神分裂症患者及其未受影响的（非精神病）兄弟姐妹（n=26 对）以及对照组及其兄弟姐妹（n=40 对）中测量了额上、中、下回的灰质体积、皮质厚度和表面积。
结果
与对照组相比，精神分裂症患者的中、下回的灰质体积减少。然而，只有精神分裂症患者未受影响的兄弟姐妹的下回体积也减少了，其体积介于受影响的兄弟姐妹和对照组之间。
结论
前额皮质亚区的结构可能受到精神分裂症遗传因素的不同影响，下回体积与家族风险的关系最为密切。
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