基质细胞衍生因子-1/趋化因子受体 4 系统在心肌梗死中的作用。
Role of the SDF-1/CXCR4 system in myocardial infarction.
机构信息
Division of Bioimaging Sciences, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.
出版信息
Circ J. 2010 Mar;74(3):418-23. doi: 10.1253/circj.cj-09-1021. Epub 2010 Jan 30.
Myocardial infarction (MI) is accompanied by an inflammatory response, leading to the recruitment of leukocytes and subsequent myocardial injury and healing. Chemokines are potent chemoattractant cytokines that regulate leukocyte trafficking in inflammatory processes. Recent evidence indicates that chemokines play a role not only in leukocyte trafficking but also in angiogenesis and cardioprotection. In particular, stromal cell-derived factor-1alpha (SDF-1alpha) has generated considerable interest for its role in the pathophysiology of MI. This review will focus on the role of SDF-1 and its receptor CXC chemokine receptor 4 (CXCR4; ie, the SDF-1/CXCR4 system) in the pathophysiology of MI and discuss their potential as therapeutic targets for MI.
心肌梗死 (MI) 伴随着炎症反应，导致白细胞的募集和随后的心肌损伤和愈合。趋化因子是调节炎症过程中白细胞迁移的强效趋化细胞因子。最近的证据表明，趋化因子不仅在白细胞迁移中发挥作用，而且在血管生成和心脏保护中发挥作用。特别是基质细胞衍生因子-1α (SDF-1α) 在 MI 的病理生理学中的作用引起了广泛的关注。这篇综述将重点介绍 SDF-1 及其受体 CXC 趋化因子受体 4 (CXCR4；即 SDF-1/CXCR4 系统) 在 MI 的病理生理学中的作用，并讨论它们作为 MI 治疗靶点的潜力。
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