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本文引用的文献

1
Co-translational mRNA decay in Saccharomyces cerevisiae.酿酒酵母中的共翻译mRNA衰变
Nature. 2009 Sep 10;461(7261):225-9. doi: 10.1038/nature08265. Epub 2009 Aug 23.
2
Processing bodies are not required for mammalian nonsense-mediated mRNA decay.哺乳动物无义介导的mRNA降解不需要加工小体。
RNA. 2009 Jul;15(7):1265-73. doi: 10.1261/rna.1672509. Epub 2009 May 27.
3
SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells.SMG6促进人类细胞中无义mRNA的核酸内切酶切割。
Nat Struct Mol Biol. 2009 Jan;16(1):49-55. doi: 10.1038/nsmb.1530. Epub 2008 Dec 7.
4
Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.Upf1磷酸化在无义介导的mRNA衰变过程中触发翻译抑制。
Cell. 2008 Apr 18;133(2):314-27. doi: 10.1016/j.cell.2008.02.030.
5
Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae.Edc3p和Lsm4p富含谷氨酰胺/天冬酰胺的结构域在酿酒酵母的加工体组装中发挥作用。
J Cell Biol. 2007 Nov 5;179(3):437-49. doi: 10.1083/jcb.200704147.
6
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.真核生物mRNA的质量控制：保护细胞免受异常mRNA功能的影响。
Genes Dev. 2007 Aug 1;21(15):1833-56. doi: 10.1101/gad.1566807.
7
mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.信使核糖核酸质量控制：一种古老的机制识别并降解带有无义密码子的信使核糖核酸。
FEBS Lett. 2007 Jun 19;581(15):2845-53. doi: 10.1016/j.febslet.2007.05.027. Epub 2007 May 21.
8
Targeting of aberrant mRNAs to cytoplasmic processing bodies.将异常mRNA靶向细胞质加工小体。
Cell. 2006 Jun 16;125(6):1095-109. doi: 10.1016/j.cell.2006.04.037.
9
Early nonsense: mRNA decay solves a translational problem.早期无义现象：mRNA降解解决了一个翻译问题。
Nat Rev Mol Cell Biol. 2006 Jun;7(6):415-25. doi: 10.1038/nrm1942.
10
General translational repression by activators of mRNA decapping.mRNA脱帽激活因子引起的普遍翻译抑制
Cell. 2005 Sep 23;122(6):875-86. doi: 10.1016/j.cell.2005.07.012.

无义介导的 mRNA 去帽反应发生在酿酒酵母的多核糖体上。

Nonsense-mediated mRNA decapping occurs on polyribosomes in Saccharomyces cerevisiae.

机构信息

Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio, USA.

出版信息

Nat Struct Mol Biol. 2010 Feb;17(2):244-7. doi: 10.1038/nsmb.1734. Epub 2010 Jan 31.

DOI:10.1038/nsmb.1734
PMID:20118937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2840703/
Abstract

Nonsense-mediated decay (NMD) degrades mRNA containing premature translation termination codons. In yeast, NMD substrates are decapped and digested exonucleolytically from the 5' end. Despite the requirement for translation in recognition, degradation of nonsense-containing mRNA is considered to occur in ribosome-free cytoplasmic P bodies. We show decapped nonsense-containing mRNA associate with polyribosomes, indicating that recognition and degradation are tightly coupled and that polyribosomes are major sites for degradation of aberrant mRNAs.

摘要

无意义介导的衰变 (NMD) 降解含有过早翻译终止密码子的 mRNA。在酵母中，NMD 底物从 5' 端被脱帽并进行外切核酸酶消化。尽管在识别中需要翻译，但含有无意义的 mRNA 的降解被认为发生在核糖体游离的细胞质 P 体中。我们发现脱帽的含有无意义的 mRNA 与多核糖体结合，这表明识别和降解紧密偶联，并且多核糖体是异常 mRNA 降解的主要部位。