干细胞治疗：拼图的碎片。
Stem cell therapy: pieces of the puzzle.
机构信息
Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, MRB IV P425C, 2213 Garland Avenue, Nashville, TN 37232, USA.
出版信息
J Cardiovasc Transl Res. 2010 Feb;3(1):49-60. doi: 10.1007/s12265-009-9148-z. Epub 2009 Nov 19.
Abstract
Acute ischemic injury and chronic cardiomyopathies can cause irreversible loss of cardiac tissue leading to heart failure. Cellular therapy offers a new paradigm for treatment of heart disease. Stem cell therapies in animal models show that transplantation of various cell preparations improves ventricular function after injury. The first clinical trials in patients produced some encouraging results, despite limited evidence for the long-term survival of transplanted cells. Ongoing research at the bench and the bedside aims to compare sources of donor cells, test methods of cell delivery, improve myocardial homing, bolster cell survival, and promote cardiomyocyte differentiation. This article reviews progress toward these goals.
摘要
急性缺血性损伤和慢性心肌病可导致心脏组织不可逆转的损失，进而导致心力衰竭。细胞疗法为心脏病的治疗提供了一种新的模式。动物模型中的干细胞疗法表明，各种细胞制剂的移植可改善损伤后的心室功能。尽管用于移植细胞长期存活的证据有限，但在患者中的首次临床试验仍取得了一些令人鼓舞的结果。目前，基础和临床研究旨在比较供体细胞的来源，测试细胞输送的方法，改善心肌归巢，增强细胞存活，并促进心肌细胞分化。本文综述了在这些目标方面取得的进展。
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